Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques

The Journal of Immunology : Official Journal of the American Association of Immunologists
Diego A Vargas-InchausteguiMarjorie Robert-Guroff

Abstract

Measurement of Ag-specific T follicular helper (TFH) cell activity in rhesus macaques has not previously been reported. Given that rhesus macaques are the animal model of choice for evaluating protective efficacy of HIV/SIV vaccine candidates and that TFH cells play a pivotal role in aiding B cell maturation, quantifying vaccine induction of HIV/SIV-specific TFH cells would greatly benefit vaccine development. In this study, we quantified SIV Env-specific IL-21-producing TFH cells for the first time, to our knowledge, in a nonhuman primate vaccine study. Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV Env, Rev, Gag, and Nef followed by two i.m. boosts with monomeric SIV gp120 or oligomeric SIV gp140 proteins. At 2 wk after the second protein boost, we obtained lymph node biopsy specimens and quantified the frequency of total and SIV Env-specific IL-21(+) TFH cells and total germinal center B cells, the size and number of germinal centers, and the frequency of SIV-specific Ab-secreting cells in B cell zones. Multiple correlation analyses established the importance of TFH for development of B cell responses in systemic and mucosally localized compartments, including blood, bone m...Continue Reading

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Citations

Jan 31, 2017·Immunological Reviews·Colin Havenar-DaughtonShane Crotty
Jan 31, 2017·Immunological Reviews·Persephone Borrow, M Anthony Moody
Apr 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenjin FanQingsheng Li
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Mar 15, 2018·Frontiers in Immunology·Monica Vaccari, Genoveffa Franchini
Mar 5, 2020·Scientific Reports·Samantha ErwinStanca M Ciupe
Oct 11, 2017·Médecine sciences : M/S·Angeline RouersStéphanie Graff-Dubois
Jul 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuan WangAlexander D Douglas
Mar 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad Arif RahmanMarjorie Robert-Guroff
Jul 12, 2020·International Journal of Molecular Sciences·Selas T F Bots, Rob C Hoeben
Jun 19, 2018·The Journal of Clinical Investigation·Eirini MoysiSavita Pahwa
Jun 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer M DanShane Crotty

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