PMID: 9164767Jun 1, 1997Paper

Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States. The Vaccine Safety Datalink Team

Pediatrics
R ChenS Hadler

Abstract

To fill the large "gaps and limitations" in current scientific knowledge of rare vaccine adverse events identified in recent reviews of the Institute of Medicine. Computerized information on immunization, medical outcomes, and potential confounders on more than 500 000 children 0 to 6 years of age is linked annually at several health maintenance organizations to create a large cohort for multiple epidemiologic studies of vaccine safety. Analysis of 3 years of follow-up data shows that 549 488 doses of diphtheria-tetanus-pertussis (DTP) and 310 618 doses of measles-mumps-rubella (MMR) vaccines have been administered to children in the study cohort. Analyses for associations between vaccines and 34 medical outcomes are underway. Screening of automated data shows that seizures are associated with receipt of DTP on the same day (relative risk [RR], 2.1; 95% confidence interval [CI], 1.1 to 4.0) and 8 to 14 days after receipt of MMR (RR, 3.0; 95% CI, 2.1 to 4.2). The diversity of vaccination exposures in this large cohort permits us to show that an apparent association of seizures 8 to 14 days after Haemophilus influenzae type b vaccine (RR, 1.6; 95% CI, 1.2 to 2.1) was attributable to confounding by simultaneous MMR vaccination; th...Continue Reading

Citations

Mar 20, 2002·Current Allergy Reports·J W Georgitis, M B Fasano
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Kari BohlkeUNKNOWN Vaccine Safety Datalink Team
May 4, 2004·Vaccine·Ville Postila, Terhi Kilpi
Jun 12, 2002·Vaccine·Liam SmeethPeter G Smith
Nov 24, 1999·Vaccine·R T Chen
Mar 5, 2002·Journal of Midwifery & Women's Health·Barbara K Hackley
Dec 17, 1998·The New England Journal of Medicine·T LaskyR T Chen
Jan 29, 2000·The New England Journal of Medicine·H S IzurietaK Fukuda
Sep 8, 2001·The New England Journal of Medicine·W E BarlowUNKNOWN Centers for Disease Control and Prevention Vaccine Safety Datalink Working Group
Sep 28, 2007·The New England Journal of Medicine·William W ThompsonUNKNOWN Vaccine Safety Datalink Team
Dec 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K L GoldenthalA Geber
Dec 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R T ChenB Patel
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale J HuTimothy D Mastro
Jul 26, 2011·Journal of Pediatric Psychology·John P BarileWilliam W Thompson
Feb 6, 1999·Public Health Reports·A Robbins, P Freeman
Feb 13, 2003·The American Journal of Nursing·Karen E Mera, Barbara Hackley
Sep 23, 2000·The Pediatric Infectious Disease Journal·E D BelayL B Schonberger
May 3, 2001·The Pediatric Infectious Disease Journal·P KramarzJ M Ogren
Dec 6, 2001·The Pediatric Infectious Disease Journal·E LewisUNKNOWN Vaccine Safety Datalink Workgroup
Aug 17, 2002·The Pediatric Infectious Disease Journal·Frank DeStefanoUNKNOWN Vaccine Safety Datalink Research Group
Apr 9, 2004·The Pediatric Infectious Disease Journal·Frederick VarricchioRobert T Chen
Jun 15, 2004·The Pediatric Infectious Disease Journal·Dorothy L MooreUNKNOWN Members of the Canadian Paediatric Society/Health Canada Immunization Monitoring Program Active (IMPACT)
Aug 31, 2006·The Pediatric Infectious Disease Journal·Paula RayUNKNOWN Vaccine Safety Datalink Group
Jul 28, 2006·Pediatric Emergency Care·Franz E BablLance Brown
Apr 9, 2005·Journal of Paediatrics and Child Health·David IsaacsJohn McEwen
Oct 5, 2001·Clinical Microbiology Reviews·P H Dennehy
Jan 1, 2010·Journal of Biomedicine & Biotechnology·Yongqun HeRobert T Chen
Nov 30, 2005·BMC Pediatrics·Nancy D LinUNKNOWN Vaccine Safety Datalink Group
Jul 14, 2004·American Journal of Public Health·Daniel A SalmonNeal A Halsey
Aug 18, 2000·Paediatric Drugs·R T ChenF DeStefano

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