Vaccines against malaria-still a long way to go

The FEBS Journal
Kai Matuschewski

Abstract

Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multiorgan failure. In malaria-endemic countries, continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity. Herein, three principal concepts in evidence-based malaria vaccine development are compared. Feasible leads are typically stand-alone subunit vaccine approaches that block Plasmodium parasite life cycle progression or parasite/host interactions, and they constitute the majority of candidates in preclinical research and early clinical testing. Integrated approaches incorporate malaria antigen(s) into licensed or emerging pediatric vaccine formulations. This strategy can complement the malaria control portfolio even if the antimalarial component is only partially effective and has led to the development of the only candidate vaccine to date, na...Continue Reading

References

Jan 12, 1984·Nature·W J McAleerM R Hilleman
Apr 4, 2002·The Journal of Infectious Diseases·Stephen L HoffmanThomas L Richie
Dec 26, 2002·Annual Review of Immunology·Rolf M Zinkernagel
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elodie BelnoueLaurent Rénia
Jan 1, 1991·Parasitology Today·B GreenwoodR Snow
Aug 20, 2005·Trends in Parasitology·Georges SnounouLaurent Rénia
Jun 13, 2006·Current Opinion in Immunology·Kai Matuschewski
Sep 11, 2007·The FEBS Journal·Renu Tuteja
Sep 11, 2007·The FEBS Journal·Kai Matuschewski, Ann-Kristin Mueller
Nov 28, 2007·Annual Review of Pathology·Kasturi HaldarTerrie E Taylor
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
May 13, 2009·The Journal of Infectious Diseases·Elyzana Dewi PutriantiKai Matuschewski
Jun 6, 2009·Current Opinion in Immunology·Sofia Casares, Thomas L Richie
Oct 7, 2009·Human Vaccines·Joe CohenAmanda Leach
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter D CromptonSusan K Pierce
Jul 16, 2010·Science Translational Medicine·Johannes FriesenSteffen Borrmann
Dec 3, 2010·The Journal of Clinical Investigation·Peter D CromptonLouis H Miller
Dec 24, 2010·Nature Reviews. Immunology·Robert W SauerweinVasee S Moorthy
Feb 12, 2011·PLoS Medicine·UNKNOWN malERA Consultative Group on Vaccines
Feb 26, 2011·Immunological Reviews·Julius Clemence HafallaKai Matuschewski
Jul 2, 2011·Current Opinion in Immunology·Steffen Borrmann, Kai Matuschewski
Jul 9, 2011·Trends in Molecular Medicine·Steffen Borrmann, Kai Matuschewski
Jul 9, 2011·Nature Immunology·Bali Pulendran, Rafi Ahmed
Oct 20, 2011·The New England Journal of Medicine·UNKNOWN RTS,S Clinical Trials PartnershipPreeti Vansadia
Sep 19, 2012·The Journal of Cell Biology·Alan F CowmanJake Baum
Dec 20, 2012·Human Vaccines & Immunotherapeutics·Kai Matuschewski
Feb 8, 2013·Nature Medicine·Eleanor M Riley, V Ann Stewart
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia PortugalPeter D Crompton
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ian A CockburnRobert Ménard
Mar 19, 2014·Journal of Internal Medicine·C Arama, M Troye-Blomberg
Jun 26, 2014·Parasitology·P J Keeling, J C Rayner
Dec 6, 2014·Frontiers in Microbiology·Johanna N DupsIan A Cockburn
Feb 14, 2015·Nature Reviews. Immunology·Tomohiro KurosakiWataru Ise
May 25, 2015·Advances in Parasitology·Yimin WuVidadi Yusibov
Oct 16, 2015·Vaccine·Michal Fried, Patrick E Duffy
Jun 30, 2016·The New England Journal of Medicine·Ally OlotuPhilip Bejon
Jul 28, 2016·Expert Review of Vaccines·Arnaud M DidierlaurentNathalie Garçon
Oct 31, 2016·Trends in Parasitology·Andrew TeoStephen J Rogerson

❮ Previous
Next ❯

Citations

Jun 19, 2017·Travel Medicine and Infectious Disease·Patricia SchlagenhaufMartin P Grobusch
Nov 14, 2017·Viral Immunology·Stanley A Plotkin
May 28, 2019·The EMBO Journal·Benjamin SprengFriedrich Frischknecht
Nov 5, 2019·Expert Opinion on Therapeutic Targets·Stanley C XieLeann Tilley
Aug 24, 2017·The FEBS Journal·Renu Tuteja
Apr 27, 2018·Microbiology and Molecular Biology Reviews : MMBR·Hyun Jae LeeAubrey J Cunnington
Aug 2, 2019·The EMBO Journal·Benjamin SprengFriedrich Frischknecht
Feb 23, 2020·Seminars in Immunopathology·Mathias SchmalerClaudia Daubenberger
Jun 6, 2018·Frontiers in Microbiology·Wei WangQijun Chen
May 5, 2018·Frontiers in Immunology·Nana K MinkahStefan H I Kappe
Oct 22, 2019·Epigenetics Insights·Todd Lenz, Karine G Le Roch
Oct 12, 2020·Trends in Parasitology·Paul M Selzer, Christian Epe
Dec 22, 2017·Emerging Topics in Life Sciences·Catherine J Merrick
Mar 20, 2021·Risk Management and Healthcare Policy·Navneet AroraAshok K Pannu
Apr 10, 2019·Journal of Medicinal Chemistry·Thomas ChevietSuzanne Peyrottes
Dec 15, 2020·ACS Biomaterials Science & Engineering·Lampouguin Yenkoidiok-Douti, Christopher M Jewell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.