Vaccines and the association with relapses in patients with neuromyelitis optica spectrum disorder

Multiple Sclerosis and Related Disorders
Maureen A MealyMichael Levy

Abstract

It is unknown if vaccines cause non-specific immune activation in patients with neuromyelitis optica spectrum disorder and no consensus on the use of vaccines exists for this population. We investigated the temporal association of vaccinations with relapses in patients with neuromyelitis optica spectrum disorder. This is a multi-center retrospective analysis of patients with neuromyelitis optica spectrum disorder for whom immunization history and clinical records from disease onset were available. Ninety patients who met 2015 diagnostic criteria received a total of 211 vaccinations and experienced 340 relapses over a median disease course of 6.6 years. The likelihood of a relapse occurring within 30, 60, and 90 days of a vaccine was compared to the likelihood of a relapse occurring within each time point of a randomly generated date. We also compared the relapse rate between patients who received any vaccination(s) after disease onset to those who did not. We identified seven patients with neuromyelitis optica spectrum disorder who relapsed within 30 days of a vaccination, six between 31 and 60 days, and four who relapsed between 61 and 90 days. The rate of vaccine-associated relapses within 30, 60, and 90 days was significantl...Continue Reading

Citations

Oct 5, 2020·Journal of Neurology·Trygve HolmøyØivind Torkildsen
Oct 24, 2020·Nature Reviews. Disease Primers·Sven JariusBrigitte Wildemann
May 18, 2021·Journal of Neuroimmunology·Hannah KellyHesham Abboud
Jul 3, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ismail Solmaz, Banu Anlar
Aug 11, 2021·Multiple Sclerosis and Related Disorders·Itay LotanMichael Levy

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