Vaccines Directed Against Microorganisms or Their Products Present During Biofilm Lifestyle: Can We Make a Translation as a Broad Biological Model to Tuberculosis?

Frontiers in Microbiology
Mario A Flores-Valdez

Abstract

Tuberculosis (TB) remains as a global public health problem. In recent years, experimental evidence suggesting the relevance of in vitro pellicle (a type of biofilm formed at the air-liquid interface) production as a phenotype mimicking aspects found by Mycobacterium tuberculosis-complex bacteria during in vivo infection has started to accumulate. There are still opportunities for better diagnostic tools, therapeutic molecules as well as new vaccine candidates to assist in TB control programs worldwide and particularly in less developed nations. Regarding vaccines, despite the availability of a live, attenuated strain (Mycobacterium bovis BCG) since almost a century ago, its variable efficacy and lack of protection against pulmonary and latent disease has prompted basic and applied research leading to preclinical and clinical evaluation of up to 15 new candidates. In this work, I present examples of vaccines based on whole cells grown as biofilms, or specific proteins expressed under such condition, and the effect they have shown in relevant animal models or directly in the natural host. I also discuss why it might be worthwhile to explore these approaches, for constructing and developing new vaccine candidates for testing thei...Continue Reading

References

Jan 1, 1977·Annual Review of Medicine·T C Eickhoff
Jul 14, 2005·Nature Reviews. Microbiology·Peter Andersen, T Mark Doherty
May 20, 2006·Nature Reviews. Microbiology·Yasir A W Skeiky, Jerald C Sadoff
Dec 23, 2011·Vaccine·Manjunatha M VenkataswamySteven A Porcelli
Jul 18, 2012·Infection and Immunity·Mohammad ShahrooeiJohan Van Eldere
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Feng WangPeter G Schultz
Oct 26, 2013·Tuberculosis·Ian M Orme
Jan 24, 2014·Pathogens and Disease·Patrick W KernsMark E Shirtliff
Jan 31, 2014·Pathogens and Disease·David F AckartRandall J Basaraba
Sep 24, 2014·Fish & Shellfish Immunology·Prabhugouda SiriyappagouderOmkar V Byadgi
Apr 7, 2015·International Journal of Biological Macromolecules·Nisha NairRaja Biswas
Jun 4, 2015·Emerging Microbes & Infections·Daan de GouwFrits R Mooi
Jun 26, 2015·Clinical and Vaccine Immunology : CVI·A D WhiteS A Sharpe

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Citations

Sep 22, 2017·Infection and Immunity·Michael J Brennan
Nov 8, 2017·Animal Health Research Reviews·Skander HathroubiMario Jacques
Jun 28, 2018·Frontiers in Microbiology·Mario A Flores-ValdezAngelo A Izzo
Feb 20, 2021·Expert Review of Vaccines·Abraham Loera-MuroCarlos Angulo
Apr 3, 2020·Journal of Microbiology and Biotechnology·Miguel Angel De la Cruz-VillegasJorge Bravo-Madrigal
Jun 16, 2021·Scientific Reports·Michel de Jesús Aceves-SánchezMaría Guadalupe Jorge-Espinoza
Dec 12, 2020·ACS Biomaterials Science & Engineering·Trevor B Donadt, Rong Yang

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