Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now

Clinical and Vaccine Immunology : CVI
Timothy F Murphy

Abstract

Infections due to nontypeable Haemophilus influenzae result in enormous global morbidity in two clinical settings: otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Recurrent otitis media affects up to 20% of children and results in hearing loss, delays in speech and language development and, in developing countries, chronic suppurative otitis media. Infections in people with COPD result in clinic and emergency room visits, hospital admissions, and respiratory failure. An effective vaccine would prevent morbidity, help control health care costs, and reduce antibiotic use, a major contributor to the global crisis in bacterial antibiotic resistance. The widespread use of the pneumococcal conjugate vaccines is causing a relative increase in H. influenzae otitis media. The partial protection against H. influenzae otitis media induced by the pneumococcal H. influenzae protein D conjugate vaccine represents a proof of principle of the feasibility of a vaccine for nontypeable H. influenzae. An ideal vaccine antigen should be conserved among strains, have abundant epitopes on the bacterial surface, be immunogenic, and induce protective immune responses. Several surfac...Continue Reading

References

Dec 1, 1989·The Journal of Infectious Diseases·H FadenP L Ogra
Jun 8, 1995·The New England Journal of Medicine·S Berman
May 24, 1995·JAMA : the Journal of the American Medical Association·J C PostG D Ehrlich
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J W St GemeS J Barenkamp
Nov 14, 1997·Journal of Clinical Microbiology·P H HendolinJ J Wahlfors
Feb 5, 1998·JAMA : the Journal of the American Medical Association·M G RaynerG D Ehrlich
Mar 6, 1998·Infection and Immunity·S M LoosmoreM H Klein
Jul 31, 2001·European Journal of Pediatrics·H Faden
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yingchun Hou, Xin-Xing Gu
Sep 2, 2003·Pediatrics·Peggy AuingerMona E Mansour
Sep 14, 2004·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero
Feb 26, 2005·Infection and Immunity·Lauren O BakaletzRobert S Munson
Mar 23, 2005·Vaccine·Timothy F MurphyDavid L Klein
Feb 3, 2006·The European Respiratory Journal·A D LopezS Buist

❮ Previous
Next ❯

Citations

Feb 9, 2016·Expert Review of Anti-infective Therapy·Nicola PrincipiSusanna Esposito
May 14, 2016·Human Vaccines & Immunotherapeutics·Marina Cerquetti, Maria Giufrè
Mar 17, 2016·Annual Review of Pathology·Rosemary J Boyton, Daniel M Altmann
Jun 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara Kędzierska, Finbarr Hayes
Sep 9, 2016·Nature Reviews. Disease Primers·Anne G M SchilderRoderick P Venekamp
Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cristina Prat, Alicia Lacoma
Mar 16, 2016·PloS One·Jennifer M Kress-BennettBenjamin A Janto
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Melinda M PettigrewTimothy F Murphy
May 26, 2017·Critical Reviews in Microbiology·Krishna Bajee SriramAllan W Cripps
Apr 4, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Reiko MiyaharaMasayuki Ishida
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heidi M SoetersElizabeth C Briere
Mar 17, 2018·FEMS Microbiology Reviews·Francesca MicoliRoberto Adamo
Jun 5, 2018·Expert Review of Vaccines·Farshid Jalalvand, Kristian Riesbeck
Aug 24, 2018·Journal of Medical Microbiology·Lea Vacca MichelMichael E Pichichero
Nov 27, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kerry-Ann F O'GradyKeith Grimwood
Mar 15, 2018·Nature Communications·S HollingsheadC M Tang
Oct 25, 2017·Nature Reviews. Microbiology·William O C M CooksonMiriam F Moffatt
Sep 7, 2019·Journal of Paediatrics and Child Health·Tarryn Corkery-LavenderSafak Goktogan
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wenchao LiHao Shen
Feb 22, 2017·Emerging Infectious Diseases·Robert WhittakerUNKNOWN European Centre for Disease Prevention and Control Country Experts for Invasive Haemophilus influenzae Disease
Mar 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Melinda M PettigrewTimothy F Murphy
Feb 6, 2020·Frontiers in Microbiology·Kirsten L Bair, Anthony A Campagnari
Dec 13, 2016·Jundishapur Journal of Microbiology·Atefeh Davoudi Vijeh MotlaghHossein Asgarian-Omran
Aug 14, 2020·International Journal of Molecular Sciences·Christian WegeleJulia Borkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.