Vaccines for preventing pneumococcal infection in adults

The Cochrane Database of Systematic Reviews
K DearD Tatham


Diseases caused by Streptococcus pneumoniae (S. pneumoniae) continue to cause substantial morbidity and mortality throughout the world. Polysaccharide pneumococcal vaccines have been developed for over 50 years and may have the potential to prevent disease and death. To assess the effectiveness of polysaccharide pneumococcal vaccination in preventing disease or death in adults. Trials were identified by electronic searches of the Cochrane Central Register of Controlled Trials (CENTRAL) issue 2, 2003 (which includes the Cochrane ARI Group's specialised register); MEDLINE (January 1966 to June 2003); and EMBASE (1974 to June 2003). We searched existing literature. The bibliographies of all newly revealed studies were read in order to identify further studies. The vaccine manufacturers, the lead authors of newly identified studies not included in existing meta-analyses were contacted. A) Prospective, randomised or quasi-randomised studies comparing pneumococcal vaccines with placebo, control vaccines or no intervention.B) Case-control studies (including indirect cohort studies) assessing pneumococcal vaccine effectiveness against invasive pneumococcal disease. Cohort studies are excluded. A) Randomised studies. Trial quality asses...Continue Reading


Feb 4, 2006·BMJ : British Medical Journal·Marc J M Bonten, Jan M Prins
Nov 26, 2011·BMC Medical Informatics and Decision Making·Alex H KristAnton J Kuzel
Nov 16, 2012·Clinical Interventions in Aging·Usama AssaadAli A El-Solh
Jan 1, 2019·Expert Review of Respiratory Medicine·Paula PeyraniGlenn S Tillotson
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherMaria C Rodriguez-Barradas
Apr 26, 2005·Current Infectious Disease Reports·Tsering Y Sherpa, Howard L Leaf
Jul 20, 2006·Journal of Medical Microbiology·Stuart C Clarke
Oct 16, 2004·Expert Review of Vaccines·Jan T Poolman
Jul 12, 2007·Gerontology·Gaëtan GavazziMonique Rothan-Tondeur

❮ Previous
Next ❯

Related Concepts