PMID: 8590245Nov 15, 1995Paper

Vaccines in the treatment of cancer

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
J K Baltz

Abstract

The development of vaccines for treating cancer is discussed. The central hypothesis behind active specific immunotherapy for cancer is that tumor cells express unique antigens that tell the immune system that something about these cells is foreign. A vaccine is a way of delivering an antigen to the immune system such that immune cells recognize the antigen as foreign and destroy any cells bearing that antigen. Early trials of vaccines for treating cancer were limited by technical problems related to poor knowledge of the immune system. Recent research has focused on expression on the surfaces of antigen-presenting cells of antigenic peptides bound to major histocompatibility complex (MHC) molecules, peptide recognition by cytotoxic T cells, and the requirement for a second signal, such as the costimulatory molecule B7, for T-cell activation. Antigenic peptides constitute the "keys" that open the "locks" of T cells; the problem is that researchers have difficulty choosing the right keys from among the myriad available. Administering an adjuvant enhances the immune response by making the antigen more recognizable as foreign. Vaccine preparation techniques include peptide pulsing (a method for bosting cell-surface expression of t...Continue Reading

Citations

Sep 1, 1997·Seminars in Surgical Oncology·W A See, C J Berman
Sep 2, 2003·The Prostate·Paulette Furbert-HarrisOladipo A Oredipe

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