PMID: 9188970Jun 1, 1997Paper

Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation

Annals of Plastic Surgery
M J MorykwasW McGuirt

Abstract

A series of basic animal studies using a new subatmospheric pressure technique (The V.A.C.) to expedite wound healing are presented. The technique entails placing an open-cell foam into the wound, sealing the site with an adhesive drape, and applying subatmospheric pressure (125 mmHg below ambient) that is transmitted to the wound in a controlled manner. Utilizing a pig model, four studies were undertaken to determine the effect of subatmospheric pressure on laser Doppler-measured blood flow in the wound and adjacent tissue (N = 5), rate of granulation tissue formation (N = 10), clearance of bacteria from infected wounds (N = 5), and measurement of nutrient flow by random-pattern flap survival (N = 5). Blood flow levels increased fourfold when 125 mmHg subatmospheric pressure was applied. Significantly increased rates of granulation tissue formation (p < or = 0.05) occurred with both continuous (63.3 +/- 26.1%) and intermittent (103% +/- 35.3%) application. Tissue bacterial counts significantly decreased (p < or = 0.05) after 4 days of application. Random-pattern flap survival significantly increased (p < or = 0.05) by 21% compared to controls. We determined that the application of controlled subatmospheric pressure creates an ...Continue Reading

Citations

Aug 30, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H RysselE Köllensperger
Oct 25, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Augustin, K Herberger
Jul 16, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Dissemond
Apr 9, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Dissemond
Jun 5, 2007·Der Unfallchirurg·G HolleG Germann
Mar 14, 2009·Der Unfallchirurg·Y Kollrack, G Möllenhoff
Nov 28, 2012·Aesthetic Plastic Surgery·Benoit AyestarayJean-Baptiste Andreoletti
Jun 21, 2005·Pediatric Surgery International·Marjorie J ArcaKeith T Oldham
Feb 22, 2011·Pediatric Surgery International·Wilson W ChoiRoy M Kimble
Dec 25, 2010·Archives of Orthopaedic and Trauma Surgery·Y TanZhijun Pan
Sep 20, 2006·Langenbeck's Archives of Surgery·Ludwig Labler, Otmar Trentz
Mar 25, 2010·Surgical Endoscopy·Gunnar LoskeChristian Müller
Nov 28, 2007·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hüseyin ArslanAydin Ketani
Apr 7, 2009·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A E Canda, A Karaca
Jul 28, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·F BerrevoetR Troisi
Mar 31, 2010·Techniques in Coloproctology·A ArezzoM Morino
Jan 17, 2008·Diseases of the Colon and Rectum·Soeren Torge MeesMatthias Bruewer
Jun 14, 2012·Journal of Materials Science. Materials in Medicine·Paola LosiGiorgio Soldani
Sep 6, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·F KuehnE Klar
Aug 13, 2010·General Thoracic and Cardiovascular Surgery·Shizuyuki DohiAtsushi Amano
Nov 23, 2006·Current Diabetes Reports·Jennifer J SuessJohn S Steinberg
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Ronda S Farah, Mark D P Davis
Jan 16, 2014·The Indian Journal of Surgery·Tolga AtayVecihi Kirdemir
May 28, 2005·The Annals of Thoracic Surgery·Johan SjögrenRichard Ingemansson
Apr 4, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Gülsüm Tetik MenevşeIbrahim Tekdemir
Apr 15, 2004·Burns : Journal of the International Society for Burn Injuries·Winston McEwanMichael J Muller
Oct 5, 2014·Clinics in Podiatric Medicine and Surgery·Crystal L RamanujamThomas Zgonis
Feb 2, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Eugene G Chio, Amit Agrawal
Feb 10, 2004·Gynecologic Oncology·Veronica L SchimpPedro T Ramirez
Mar 28, 2001·The Annals of Thoracic Surgery·S E GreerM T Longaker
Dec 12, 2003·The Annals of Thoracic Surgery·Ronny I GustafssonRichard Ingemansson
Jan 5, 2000·The Annals of Thoracic Surgery·M C ObdeijnW J de Boer
Dec 31, 2003·The Journal of Surgical Research·Anne M ConquestW Randolph Chitwood
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Patrick W DomkowskiWalter G Wolfe
Nov 11, 2003·Obstetrics and Gynecology·Hyun S ShvartsmanLois M Ramondetta
Jul 24, 2001·The Orthopedic Clinics of North America·C Attinger, P Cooper
Nov 24, 2001·Burns : Journal of the International Society for Burn Injuries·K P ChangS D Lin

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