PMID: 11323123Apr 27, 2001Paper

Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain

Pain
T MichlP Holzer

Abstract

Although gastric acid is a factor in upper abdominal pain, the signaling and processing of a gastric mucosal acid insult within the brain are not known. This study examined which nuclei in the rat brain respond to challenge of the gastric mucosa by a noxious concentration of hydrochloric acid (HCl) and whether the central input is carried by vagal afferent neurons. Activation of neurons in the brain was mapped by in situ hybridization autoradiography of messenger ribonucleic acid (mRNA) for the immediate early gene c-fos 45 min after intragastric administration of saline or HCl. Following intragastric HCl (0.5 M) challenge, many neurons in the nucleus tractus solitarii, lateral parabrachial nucleus, thalamic and hypothalamic paraventricular nucleus, supraoptic nucleus, central amygdala and medial/lateral habenula expressed c-fos mRNA as compared to intragastric treatment with saline (0.15 M). However, c-fos transcription in the insular cortex was not enhanced by the gastric acid insult. Hypertonic saline (0.5 M) caused only a minor expression of c-fos mRNA in the hypothalamus and amygdala. The acid-evoked c-fos induction in subcortical nuclei was depressed by at least 80% five days after bilateral subdiaphragmatic vagotomy. Col...Continue Reading

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Citations

Jun 26, 1999·Microscopy Research and Technique·L M MendellB M Davis
Dec 4, 2003·Current Opinion in Pharmacology·Peter Holzer
Nov 5, 2003·Gastroenterology·Kenneth LambKlaus Bielefeldt
Dec 17, 2002·Current Opinion in Pharmacology·Paul L R Andrews, Gareth J Sanger
May 20, 2006·Journal of Negative Results in Biomedicine·Patrick J ReynoldsMichael C Andresen
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P Holzer
Aug 5, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K BielefeldtB M Davis
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BanerjeeJ N Sengupta
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Nov 12, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C TanaS Fukudo
May 23, 2014·The Journal of Comparative Neurology·April N HerrityCharles H Hubscher
Mar 18, 2006·Autonomic Neuroscience : Basic & Clinical·Peter Holzer
Jan 18, 2006·Chinese Journal of Digestive Diseases·Fei Fei ZhangShu Dong Xiao
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Peter Holzer
Mar 10, 2016·The Journal of Physiology·Guillaume de Lartigue
Apr 17, 2007·Neuroscience Letters·Kiyoshige TakayamaShoki Ro
Oct 4, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·K DangG F Gebhart
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Nov 1, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marion DanzerPeter Holzer
Apr 21, 2018·Frontiers in Systems Neuroscience·Amanda J Page, Hui Li
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Nov 7, 2019·World Journal of Gastroenterology : WJG·Yang BaiYun-Qing Li
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·R SchichoI T Lippe

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