Vagal damage enhances polyneuropathy pain: additive effect of two algogenic mechanisms

Pain
Irit Weissman-FogelD Yarnitsky

Abstract

While the major pain generation in polyneuropathy is in the somatic peripheral nerves, pathologies at visceral nerves might be involved as well. Decreased vagal afferent activity is known to disinhibit pain perception, and therefore might contribute to pain in polyneuropathy. In this study we explored this potential contribution by employing a rat model of vincristine (VCR)-induced pain after sub-diaphragmatic vagotomy (SDV). Forty rats were divided into 4 groups: VCR, SDV, VCR+SDV and controls. Each rat underwent a variety of pain-related behavioral tests including assessment of spontaneous pain, allodynia and hyperalgesia to thermal and mechanical stimuli. We found that VCR+SDV rats had enhanced painful neuropathy compared to VCR alone, expressed as: (1) earlier development of central sensitization: at the first week in rats that underwent SDV+VCR (p<0.0001) and only at the second week in rats injected with VCR alone (p<0.0001), (2) increased incidence of spontaneous pain behavior (p=0.0036), (3) spreading of the spontaneous pain behavior to the forelimbs, (4) higher mechanical dynamic allodynia (tendency, p=0.08) and (5) augmentation of the response to repetitive painful and non-painful mechanical stimuli (p<0.001). Thus, de...Continue Reading

References

Dec 1, 1977·Journal of Comparative and Physiological Psychology·C A Opsahl, T L Powley
May 1, 1992·Brain Research. Brain Research Reviews·A Randich, G F Gebhart
Apr 1, 1994·Brain : a Journal of Neurology·S KiloH O Handwerker
May 1, 1993·Annals of Neurology·J L Ochoa, D Yarnitsky
May 1, 1993·Journal of Neurophysiology·J W LeemJ M Chung
Feb 1, 1997·Muscle & Nerve·D Yarnitsky
Sep 28, 1998·The European Journal of Neuroscience·S G KhasarJ D Levine
Dec 1, 1999·Computer Methods and Programs in Biomedicine·A E AubertH Ector
Jan 29, 2000·The European Journal of Neuroscience·M MalcangioS B McMahon
Mar 29, 2000·Progress in Brain Research·W JänigF J Miao
Nov 9, 2000·Neurology·A KirchnerH O Handwerker
Jun 19, 2001·Pain·N Nozaki-TaguchiT L Yaksh
Nov 20, 2003·Trends in Neurosciences·Ru-Rong JiClifford J Woolf
Jan 22, 2005·Pain·Oshra SedanDavid Yarnitsky

❮ Previous
Next ❯

Citations

Feb 18, 2016·Pain Practice : the Official Journal of World Institute of Pain·Hadas Nahman-AverbuchDavid Yarnitsky
Jul 12, 2011·European Journal of Pharmacology·Amteshwar Singh Jaggi, Nirmal Singh
Sep 18, 2010·European Journal of Pharmacology·Amteshwar Singh Jaggi, Nirmal Singh
Nov 12, 2015·Physiology & Behavior·Hadas Nahman-AverbuchGiris Jacob
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimJoseph L Riley
Aug 21, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Y ZhangS L Chen
Jun 19, 2013·European Journal of Pain : EJP·H Nahman-AverbuchD Yarnitsky
Sep 15, 2015·Headache·Hsiangkuo Yuan, Stephen D Silberstein
Mar 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shrutya BhallaAmteshwar Singh Jaggi
Jan 22, 2013·Journal of Ethnopharmacology·Mariane Arnoldi SilvaJuliano Ferreira
Aug 18, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nora HegazyAhmed Fahmy
Sep 17, 2021·Journal of Microencapsulation·Nitin KumarMohd Yasir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.