Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus

Journal of Neurophysiology
A J PageL Ashley Blackshaw

Abstract

We used a novel in vitro mouse vagus-gastro-esophageal preparation to study the properties of peripheral vagal afferent endings. We found two types of mechanoreceptive fiber, mucosal receptors and tension receptors. These were distinguished by their sensitivity to mucosal stroking with von Frey hairs and circular tension applied via a claw-cantilever system. A comparison was made with gastro-esophageal afferents found in a similar preparation of ferret tissue. Responses of mouse tension receptors to circular tension were significantly greater than ferret tension and tension/mucosal receptors. Similarly the responses of mouse mucosal receptors to mucosal stroking were significantly greater than ferret mucosal and tension/mucosal receptors. Forty-seven percent of mouse mucosal receptors and 50% of tension receptors responded to one or more drugs or chemical stimuli applied to the receptive field. These included alpha,beta-methylene ATP (10(-6) to 10(-3) M), 5-hydroxytryptamine (10(-6) to 10(-3) M), and hydrochloric acid (10(-2) to 10(-1) M). Drug responses were concentration dependent. One hundred percent of mucosal receptors and 61% of tension receptors tested responded to bile (1:8 to 1:1 dilution). A third type of fiber was re...Continue Reading

References

Jan 31, 1978·Pflügers Archiv : European journal of physiology·M FalempinJ P Rousseau
Sep 1, 1978·The Journal of Physiology·N Mei
Jan 1, 1990·Annals of the New York Academy of Sciences·G Burnstock
Dec 1, 1990·Journal of the Autonomic Nervous System·L A Blackshaw, D Grundy
May 1, 1989·Journal of Neurophysiology·J N SenguptaR K Goyal
Nov 1, 1986·Journal of the Autonomic Nervous System·J Mélone
Jul 1, 1988·The Journal of Physiology·F Cervero, K A Sharkey
Jul 1, 1988·The American Journal of Physiology·J S Davison, G D Clarke
Jun 1, 1988·The British Journal of Surgery·P GillenT P Hennessy
Feb 4, 1985·Brain Research·L C Hudson, J F Cummings
Oct 1, 1972·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J S Davison
Sep 1, 1984·The Journal of Physiology·D F Cottrell, A Iggo
Mar 1, 1983·The Journal of Physiology·N Clerc, N Mei
Jan 1, 1980·The Journal of Physiology·P L AndrewsT Scratcherd
Aug 1, 1996·Current Opinion in Neurobiology·G Burnstock, J N Wood
Oct 27, 1997·Journal of Neurophysiology·M KoltzenburgG R Lewin
Apr 9, 1999·Nature Neuroscience·P CarrollH Thoenen
Feb 23, 2000·Neuroscience·L A BlackshawE R Partosoedarso
Jun 28, 1955·The Journal of Physiology·A IGGO

❮ Previous
Next ❯

Citations

Aug 12, 2003·The Journal of Physiology·Marian KollarikBradley J Undem
Nov 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin Feng, G F Gebhart
Mar 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·I M LangR Shaker
Mar 18, 2008·Gastroenterology·Stuart M BrierleyL Ashley Blackshaw
Nov 30, 2014·The Journal of Physiology·Stephen J Kentish, Amanda J Page
Jun 30, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kelly L HepworthElyanne M Ratcliffe
May 23, 2014·The Journal of Comparative Neurology·April N HerrityCharles H Hubscher
Dec 26, 2012·The Journal of Physiology·Stephen J KentishAmanda J Page
Jun 5, 2013·Journal of Gastroenterology and Hepatology·Chien-Lin ChenTso-Tsai Liu
Nov 9, 2011·The Journal of Physiology·Stephen KentishAmanda J Page
Jan 20, 2011·The Journal of Comparative Neurology·Terry L PowleyStanley A Haglof
May 17, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S YuM Kollarik
Mar 22, 2012·British Journal of Pharmacology·Amanda J PageRichard L Young
Jul 2, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X-Y WangL W C Liu
Sep 2, 2006·The Journal of Physiology·James A SlatteryL Ashley Blackshaw
Jan 15, 2005·The Journal of Physiology·Shaoyong YuMarian Kollarik
Jan 8, 2005·The Journal of Physiology·Amanda J PageL Ashley Blackshaw
Jul 14, 2007·The Journal of Physiology·Amanda J PageL Ashley Blackshaw
May 5, 2007·The Journal of Physiology·Vladislav SnitsarevFrançois M Abboud
Jun 11, 2005·The Journal of Physiology·Stuart M BrierleyL Ashley Blackshaw
Mar 10, 2016·The Journal of Physiology·Guillaume de Lartigue
Oct 27, 2016·The Journal of Physiology·Stuart J McDougallMichael C Andresen
Aug 26, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Paul P Bertrand
Dec 4, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P J ByrneJ V Reynolds
Jun 10, 2010·The Journal of Comparative Neurology·Michelle C Murphy, Edward A Fox
Jul 24, 2004·Medical Engineering & Physics·Donghua LiaoHans Gregersen
Jun 5, 2007·Autonomic Neuroscience : Basic & Clinical·Philip M Lang, Peter Grafe
Feb 10, 2007·Pulmonary Pharmacology & Therapeutics·Marian KollarikBradley J Undem
Jan 14, 2009·Pulmonary Pharmacology & Therapeutics·Marian Kollarik, Mariana Brozmanova
Oct 18, 2005·Pharmacology & Therapeutics·Geoffrey Burnstock
Jun 1, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Raab, W L Neuhuber
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L A BlackshawM Schemann
Dec 2, 2009·Molecular Pain·Geoffrey Burnstock
Aug 26, 2010·Pharmaceuticals·Stuart M BrierleyL Ashley Blackshaw
Jun 27, 2003·Anesthesiology·Philip M LangPeter Grafe
Jul 31, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S J KentishA J Page
Feb 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Simon J H BrookesVladimir P Zagorodnyuk
Oct 12, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ivan M LangReza Shaker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
A J Page, L Ashley Blackshaw
American Journal of Physiology. Gastrointestinal and Liver Physiology
A J PageL Ashley Blackshaw
Autonomic Neuroscience : Basic & Clinical
Vladimir P ZagorodnyukSimon J H Brookes
© 2022 Meta ULC. All rights reserved