PMID: 9531447Apr 8, 1998Paper

Vagal nerve stimulation during muscarinic and beta-adrenergic blockade causes significant coronary artery dilation

Journal of the Autonomic Nervous System
L Feliciano, R J Henning

Abstract

Vasoactive intestinal peptide (VIP) is present in post-ganglionic vagal nerve fibers in the coronary arteries and right ventricle but no significant amounts are found in the left ventricle. We determined the effects of VIP, released endogenously from cardiac vagal nerves, on the circumflex mean coronary artery pressure and on right and left ventricular (RV and LV) contractility (dP/dtmax) and relaxation (dP/dtmin). In 20 anesthetized, open chest mongrel dogs, the cervical vagus nerves and cardiac sympathetic ansa subclaviae were isolated and transected. Electrodes were applied to the cardiac segments of the right and left vagus nerves for subsequent stimulation. The muscarinic and beta-adrenergic receptors were blocked with atropine and propranolol, respectively. The heart rate was controlled by either producing atrioventricular node block in 10 dogs and pacing the ventricles (series 1) or by right atrial pacing in 10 separate dogs (series 2). Coronary artery blood flow was controlled by perfusing the circumflex coronary artery in each dog with femoral arterial blood at a controlled flow rate. Coronary artery pressure, ventricular and aortic pressures and dP/dt were continuously measured. Experiments were performed prior to and...Continue Reading

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Citations

Jan 8, 2000·Clinical Cardiology·L Feliciano, R J Henning
Nov 8, 2001·Experimental Physiology·J F Jones
Dec 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S PesićZ Cvetković
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mridula PachenRohit Ramchandra

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