PMID: 8944815Nov 1, 1996Paper

Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate

Cardiovascular Research
R J HenningC M Coers

Abstract

To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate. The muscarinic and beta-adrenergic receptors were blocked with atropine and propranolol, and afterload was controlled in 48 anesthetized, open-chest mongrel dogs. Experiments were performed in the absence (Series 1, 10 dogs) and in the presence (Series 2, 22 dogs) of a controlled heart rate and prior to and after the administration of a sensitive and selective vasoactive intestinal peptide antagonist (Series 3, 16 dogs). Right ventricular contraction (+dp/dtmax), relaxation (-dp/dtmin) and heart rate increased significantly during 20 Hz vagal nerve stimulation for 5 min. Vagal nerve stimulation in Series 1 increased right ventricular +dp/dtmax by 28% from a control value of 480 +/- 11 (P < 0.001) and right ventricular -dp/dtmin by 23% from a control value of 341 +/- 11 (P < 0.002). Left ventricular +dp/dtmax and -dp/dtmin increased slightly but not significantly. Vagal nerve stimulation also increased the heart rate by 29% from a control value of 149 +/- 2 (P < 0.001). During controlled heart rate in Series 2, vagal nerve stimulation at 20 Hz consistently increased rig...Continue Reading

Citations

Apr 8, 1998·Journal of the Autonomic Nervous System·L Feliciano, R J Henning
Mar 13, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Serdar GunaydinToshiharu Shinoka
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H B LillywhiteA P Farrell
Apr 12, 2011·Respiratory Research·Dongmei WuYong Kiel Sung
Apr 22, 2015·Current Treatment Options in Cardiovascular Medicine·William A HuangMarmar Vaseghi
Sep 21, 2013·Circulation. Arrhythmia and Electrophysiology·Yutao XiJie Cheng

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