Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern

Seizure : the Journal of the British Epilepsy Association
Marina CasazzaGiovanni Broggi

Abstract

In recent years, vagal nerve stimulation (VNS) has been proposed as a possible way to improve the control of refractory (partial and generalized) seizures. To date, however, there is no complete understanding of the underlying mechanism for this action nor are there any available guidelines or criteria for the selection of those candidates that might be most suitable for this kind of neuromodulating surgery. This report presents evidence that should be helpful in defining the clinical criteria for using VNS for the treatment of refractory seizures. We report on 17 patients with severe partial refractory epilepsy and polymorphous seizures, who have been operated on previously or who were excluded from epilepsy surgery and for whom, at least, one seizure type has been electrographically recorded. Sixteen of these patients also had falling seizures. Our objective was to identify responders and to correlate the outcome of their seizures with the EEGraphic onset of their seizure. Follow-up ranged from 4 to 9 years. The results of this study indicate a significant reduction of seizures in only four patients and better outcome in patients where the onset of seizure activity occurred in the temporal area. Patients with frontal or front...Continue Reading

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Citations

Apr 22, 2008·Neuro-Chirurgie·F-X RouxE Landré
Aug 22, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A Laine Green, Donald F Weaver
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Oct 9, 2012·Seizure : the Journal of the British Epilepsy Association·Eduardo García-NavarreteR G Sola
Apr 7, 2010·Seizure : the Journal of the British Epilepsy Association·Kazem GhaemiAlois Ebner
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Jul 10, 2013·Epilepsy & Behavior : E&B·Carlo Efisio MarrasMaria Paola Canevini
Mar 15, 2011·Seizure : the Journal of the British Epilepsy Association·N ZamponiF Rychlicki
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Nov 15, 2020·Acta Neurologica Scandinavica·Maxine DibuéMarcel A Kamp

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