PMID: 3745775Jul 1, 1986Paper

Vagal stimulation-induced gastric acid secretion in the anesthetized rat

Journal of the Autonomic Nervous System
H R BerthoudT L Powley

Abstract

The dynamics of gastric acid secretion induced by electrical stimulation of the cervical vagus in the anesthetized rat were investigated using a continuous collection-titration system permitting high temporal resolution. Stimulation with pulse rates of 2 or 4 impulses/s (pps) produced maximal gastric acid responses with small cardiovascular effects. With continuous stimulation, secretion was sustained for at least 1 h. Frequency-response profiles suggested that the parietal cells are innervated predominantly by fine-caliber C-fibers. Continuous stimulation was 3 times as effective as stimulation in bursts of higher frequencies. The minimal latency for the onset of secretion was 2.6 min at 4 pps, however, one- and two-min stimulations still produced proportionate but delayed secretory responses. It is concluded that, with low frequency cervical vagus stimulation, the rat stomach preparation described and employed in the present experiment is a useful model for further studies on the interaction of neural and humoral factors on gastric acid secretion.

References

Aug 30, 1973·Brain Research·G Gabella, H L Pease
Feb 1, 1983·Journal of the Autonomic Nervous System·H R BerthoudB Jeanrenaud
Apr 1, 1983·Pflügers Archiv : European journal of physiology·J F SauterB Jeanrenaud
Sep 1, 1983·Acta Physiologica Scandinavica·S VallgrenR Håkanson
Oct 1, 1983·Journal of the Autonomic Nervous System·T L PowleyH R Berthoud
Nov 1, 1983·Brain Research Bulletin·J F SauterB Jeanrenaud
May 1, 1982·Acta Physiologica Scandinavica·R HåkansonS Vallgren
Mar 1, 1958·British Journal of Pharmacology and Chemotherapy·M N GHOSH, H O SCHILD

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Citations

Oct 22, 2013·American Journal of Surgery·Janaka LagooAlexander Perez
Apr 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah C RayPaul M O'Connor
Jul 28, 2006·The Journal of Comparative Neurology·Tetsu HayakawaMakoto Seki
Nov 2, 2019·Physiological Reviews·Amy C EngevikJames R Goldenring
Jan 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elinor C MannonPaul M O'Connor

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