PMID: 6543461Dec 1, 1984

Vaginal absorption of oestradiol and progesterone

Maturitas
H Kålund-Jensen, C J Myrén

Abstract

The vaginal absorption of micronized oestradiol/progesterone from a hydrophilic matrix system was investigated before and after 10 days of treatment in 7 post-menopausal women with an average age of 56.1 yr. Oestradiol and progesterone levels were measured on days 1 and 11 before administration and 0.5, 1, 2, 3, 4, 6, 8, 12, and 24 h afterwards by radioimmunoassay. Peak values were seen 6-12 h after administration. This finding differs from those of other investigations. Sex hormone binding globulin (SHBG) and androgen concentrations were unchanged after 10 days of treatment.

References

Dec 4, 1975·The New England Journal of Medicine·H K Ziel, W D Finkle
Jan 26, 1978·The New England Journal of Medicine·L A RiggS S Yen
Apr 1, 1977·Obstetrical & Gynecological Survey·W H Utian
Jan 1, 1979·Acta Obstetricia Et Gynecologica Scandinavica·T BäckströmJ Toivonen
Jun 1, 1976·Journal of Pharmaceutical Sciences·M B Aufrère, H Benson
Dec 4, 1975·The New England Journal of Medicine·D C SmithW L Herrmann
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S R PlymateA E Karpas
Oct 1, 1982·Acta Endocrinologica·V OdlindE D Johansson
Dec 1, 1980·Maturitas·R PunnonenL Rauramo

Related Concepts

Androgen Effect
Aerodiol
Menopause
Progesterone, (17 alpha)-Isomer
Sex Hormone-Binding Globulin
Rectal Suppository
Vagina

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