PMID: 3768289Sep 1, 1986Paper

Vaginal and abdominal delivery increases maternal urinary 6-keto-prostaglandin F1 alpha excretion

British Journal of Obstetrics and Gynaecology
O YlikorkalaL Viinikka

Abstract

To study the role of the antiaggregatory and vasodilatory prostacyclin (PGI2) during human delivery, serial urine samples collected from 13 women delivered vaginally and from eight delivered abdominally were assayed for 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha, a breakdown product of PGI2) by high-performance-liquid-chromatography and radioimmunoassay. In women delivered vaginally the mean urinary 6-keto-PGF1 alpha concentration was 41.9 (SE 8.3) ng/mmol creatinine, before the onset of labour and increased progressively to a maximum of 186.5 (SE 47.6) ng/mmol creatinine 2 h after delivery irrespective of the use of oxytocin and epidural analgesia. In women delivered by caesarean section under epidural anaesthesia, the urinary 6-keto-PGF1 alpha rose from 33.4 (SE 4.2) ng/mmol creatinine to 2153 (SE 314) ng/mmol creatinine 2 h after section. In both groups the increased levels had fallen by 24 h postpartum to levels below those found before delivery. In neonatal urine 6-keto-PGF1 alpha concentrations were some 12-30 times higher than those in postpartum urine. Thus, vaginal and abdominal delivery is accompanied by significant increases in maternal PGI2 release, perhaps in the myometrium and/or intrauterine tissues. This m...Continue Reading

References

Mar 1, 1985·American Journal of Obstetrics and Gynecology·P JouppilaO Ylikorkala
Jun 1, 1985·American Journal of Obstetrics and Gynecology·O Ylikorkala, U M Mäkilä
Nov 15, 1984·American Journal of Obstetrics and Gynecology·L Mäkäräinen, O Ylikorkala
Nov 1, 1983·American Journal of Obstetrics and Gynecology·M L CaseyM D Mitchell
May 1, 1981·British Journal of Obstetrics and Gynaecology·O YlikorkalaL Viinikka
Jun 1, 1982·Archives of Disease in Childhood·P KääpäO Ylikorkala
Apr 1, 1982·Prostaglandins·I A BlairC T Dollery

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Citations

Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frank Hertelendy, Tamás Zakár
Nov 27, 2008·The Journal of Clinical Investigation·Kristina M FetalveroKathleen A Martin
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·O Ylikorkala, L Viinikka
May 6, 2019·International Journal of Environmental Research and Public Health·Katherine A BirchenallAndrés López Bernal
Apr 1, 1987·British Journal of Obstetrics and Gynaecology·J Y JeremyP Dandona

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