Vaginal anomalies and atresia associated with imperforate anus: diagnosis and surgical management

Journal of Pediatric Surgery
Kartikey A PandyaDaniel H Teitelbaum

Abstract

The association of vaginal atresia (or Mayer-Rokitansky-Kuster-Hauser Syndrome) with imperforate anus is rare and can present significant diagnostic and therapeutic challenges. This study describes clinical characteristics, surgical treatment and outcomes in this group of complex children. Records of 20 patients were retrospectively analyzed from two pediatric surgical centers. Five patients were excluded from the long-term analysis due to inadequate information, leaving long-term follow-up in 15 patients. Mean follow-up was 10 years (range 1-31.1 years). The diagnosis of vaginal atresia was made pre-operatively in 12 out of 15 patients, and in three patients it was identified during the anoplasty. The anorectal malformations were rectoperineal (N=2), rectovestibular (N=6), recto-bladder neck (N=1) and imperforate anus without fistula (N=6). Satisfactory surgical repair was performed in 13 patients, while one continues to stool through a low perineal fistula awaiting definitive surgery and another underwent a colostomy and mucous fistula. Delayed vaginal reconstruction was due to a failure to identify the problem prior to anoplasty (N=3). Long-term results demonstrated that anorectal continence was much worse than initially app...Continue Reading

References

Aug 1, 1989·Journal of Pediatric Surgery·F Tolete-VelcekP K Kottmeier
Aug 1, 1971·Journal of Pediatric Surgery·S H Ein, C A Stephens
Aug 7, 1998·Journal of Pediatric Surgery·M A LevittA Peña
Jan 5, 2005·Indian Journal of Pediatrics·Shreeprasad P PatankarShilpa S Patankar
Feb 14, 2007·The Journal of Urology·Naziha Khen-DunlopClaire Nihoul-Fekete
Jul 27, 2007·Orphanet Journal of Rare Diseases·Marc A Levitt, Alberto Peña
Jun 16, 2009·Journal of Pediatric Surgery·Marc A LevittAlberto Peña
Mar 20, 2012·Journal of Pediatric Surgery·Tomas WesterRisto J Rintala
Aug 22, 2012·Reproductive Biology and Endocrinology : RB&E·Patricia G OppeltAndreas Mueller
Jun 21, 2013·Journal of Pediatric and Adolescent Gynecology·Courtney A MarshYolanda R Smith

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Citations

Dec 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Meng ZhangCong-Jian Xu

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