Vaginal colonization and activity of the probiotic bacterium Lactobacillus fermentum L23 in a murine model of vaginal tract infection

Journal of Medical Microbiology
L PascualIsabel L Barberis

Abstract

A strain of Lactobacillus, identified as Lactobacillus fermentum L23, was selected from among 100 strains isolated from vaginal swabs of healthy, non-pregnant, pre-menopausal women. L. fermentum L23 was chosen on the basis of its bacteriocinogenic ability and its properties relevant to colonization, i.e. self-aggregation, adherence to vaginal epithelial cells and co-aggregation with bacterial pathogens. The antimicrobial preventative and curative effects produced by the probiotic L. fermentum L23 administered locally against Escherichia coli in a murine vaginal tract infection model were studied. One dose of the human strain L23 containing 10(8) c.f.u. ml(-1) colonized and persisted in the vaginal tract of the female BALB/c mice for 5 days. Infection with the pathogen at 10(6) c.f.u. ml(-1) in the vaginal tract was maintained for more than 7 days. A single dose of L23 administered 24 h pre-infection inhibited E. coli growth on day 3 post-infection, showing the preventative effect displayed by this Lactobacillus strain. Treatment with L. fermentum L23 during the post-infection period showed complete inhibition of pathogen growth from day 5. Thus, this in vivo study indicated that the probiotic bacterium L. fermentum L23 produced...Continue Reading

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Citations

May 19, 2011·Future Microbiology·Rachel R Spurbeck, Cindy Grove Arvidson
Oct 1, 2014·International Journal of Food Microbiology·Joana BarbosaPaula Teixeira
Aug 15, 2015·Genome Announcements·A V ChaplinL I Kafarskaia
Jan 17, 2014·Virulence·Rebeca MartínLuis G Bermúdez-Humarán
Nov 12, 2016·Frontiers in Microbiology·Monique S do CarmoValério Monteiro-Neto
May 29, 2012·Antonie van Leeuwenhoek·Priscilla Romina De GregorioMaría Elena Fatima Nader-Macías
Aug 8, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·O RotenbergP Dar
Jan 21, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Kevin DeLongLaura M Ensign
Dec 12, 2017·BioMed Research International·Wallace Felipe Blohem PessoaCarla Cristina Romano
Nov 8, 2020·International Journal of Molecular Sciences·Guillaume LacroixJean-Luc Desseyn

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