Vaginal incisional wound healing in a rabbit menopause model: a histologic analysis.

International Urogynecology Journal
Y AbramovP K Sand

Abstract

INTODUCTION AND HYPOTHESIS: The vaginal wound healing process is a major determinant of surgical outcome following pelvic reconstructive surgery. Since the majority of these surgeries are performed in peri- and postmenopausal women, it is essential to understand how estrogen deficiency affects this process. We aimed to histologically evaluate the vaginal incisional wound healing process in a rabbit menopause model. Sixty three rabbits were utilized and divided into 3 groups: Twenty one underwent bilateral oophorectomy, 21 underwent a sham surgery, and 21 served as controls. Eight weeks later, standardized full-thickness 6 mm circular segments were excised from the vagina of all rabbits and spontaneous healing was recorded. Animals were euthanized sequentially, before wounding, and at 0, 4, 7, 14, 21 and 35 days after wounding, and their wounds were harvested and assessed histologically for wound healing using a validated scoring system. Oophorectomized rabbits showed significantly delayed wound closure (p < 0.02), neovascularization (p < 0.01), granulation tissue accumulation and maturation (p < 0.02), collagen deposition (p < 0.01) and re-epithelialization (p < 0.01), however acute and chronic inflammation were significantly e...Continue Reading

References

Nov 1, 1987·Fertility and Sterility·W D SchlaffJ A Rock
Aug 1, 1993·The Journal of Dermatologic Surgery and Oncology·R A Clark
Apr 1, 1997·Obstetrics and Gynecology·A L OlsenA L Clark
Mar 21, 1998·British Journal of Obstetrics and Gynaecology·M CalvinS R Young
Apr 11, 2003·The Journal of Urology·Andrew J WalterJeffrey L Cornella
May 3, 2003·The Journal of Clinical Investigation·Gillian S AshcroftToshinori Nakayama
Nov 7, 2006·Climacteric : the Journal of the International Menopause Society·C HainesA Husband
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yoram AbramovPeter K Sand
Aug 18, 2009·American Journal of Obstetrics and Gynecology·Edmund W HigginsLisa M Pierce
Sep 11, 2010·Fertility and Sterility·Yoram AbramovPeter K Sand

❮ Previous
Next ❯

Citations

Jan 9, 2014·Expert Opinion on Drug Discovery·Pamela Cmd ZanniMárcia El Consolaro
Nov 8, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Natália Gomes ParizziVictor Hugo Tolotto de Carvalho
Jul 15, 2021·Female Pelvic Medicine & Reconstructive Surgery·Katarzyna BochenskaChristina Lewicky-Gaupp
Oct 14, 2021·Neurourology and Urodynamics·Eva V VodegelZeliha Guler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.