PMID: 9174833Jan 1, 1997Paper

Vaginal intraepithelial neoplasia (VAIN) following hysterectomy in patients treated for carcinoma in situ of the cervix

European Journal of Gynaecological Oncology
D KalogirouL Giannikos

Abstract

To determine the number of patients with carcinoma in situ of the cervix treated by hysterectomy who proceeded to develop vaginal intraepithelial neoplasia (VAIN) and define whether the subsequent development of VAIN justifies intensive cytology and colposcopy follow-up. Nine hundred and ninety-three women who were subjected to hysterectomy with CIN, (793 patients had completed 10 years of cytology and colposcopy follow-up) were identified. Forty-one patients with VAIN presented with CIN 3 after hysterectomy. The upper one half of the vagina was the area more affected. The middle age group developed VAIN in the shortest time. Atypical Cells (ASCUS) were found in 42% of these patients. Colposcopy revealed VAIN involving the vault angles of the suture line in 54% of the cases. In 51% of the cases the grade of vaginal abnormality was the same as that of the original lesion in the cervix. With such data we would propose screening over a 5-year period. Follow-up should also include colposcopic review during every examination.

Citations

Apr 18, 2006·Irish Journal of Medical Science·C CoughlanN Gleeson
Mar 19, 2013·Gynécologie, obstétrique & fertilité·F NicolasJ Levêque
Dec 9, 2008·Obstetrics and Gynecology Clinics of North America·Alan G Waxman
Dec 9, 2008·Obstetrics and Gynecology Clinics of North America·Hélène M Gagné
Nov 4, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·H Stokes-LampardS Kehoe
Feb 25, 2010·The Journal of Obstetrics and Gynaecology Research·Sathone Boonlikit, Nattakul Noinual
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Jan 29, 2002·Gynecologic Oncology·Janet R DalingHisham Tamimi
Nov 15, 2005·International Journal of Cancer. Journal International Du Cancer·William Patrick SoutterTheo Panoskaltsis
Jan 9, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mikel GorostidiGlauco Baiocchi
Nov 27, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·Emilia AlfonzoBjörn Strander

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