Vaginal misoprostol versus concentrated oxytocin and vaginal PGE2 for second-trimester labor induction

Obstetrics and Gynecology
Patrick S RamseyJ Owen

Abstract

To compare the efficacy, side effects, and complications of high-dose vaginal misoprostol with concentrated intravenous oxytocin plus low-dose vaginal prostaglandin (PGE(2)) for second-trimester labor induction. One hundred twenty-six consenting women with maternal or fetal indications for pregnancy termination and no prior cesarean delivery were randomly assigned to receive either vaginal misoprostol 600 microg 1x, 400 microg every 4 hours 5x (misoprostol group, n = 60) or escalating-dose concentrated oxytocin infusions (277-1,667 mU/min) plus vaginal PGE(2) 10 mg every 6 hours 4x (oxytocin group, n = 66). Both groups received concurrent extra-amniotic saline infusion for cervical ripening. Women who failed their assigned regimen received 20 mg of PGE(2) suppositories every 4 hours until delivery. Analysis was by intent to treat. Demographic characteristics were similar between study groups. Median induction-to-delivery interval was significantly shorter in the misoprostol group (12 hours) than in the oxytocin group (17 hours; P <.001). There was a higher induction success rate at 24 hours in the misoprostol group (95%) than in the oxytocin group (85%; P =.06), although this difference did not reach statistical significance. T...Continue Reading

References

Jun 1, 1995·American Journal of Obstetrics and Gynecology·D A WingR H Paul
Aug 4, 1994·The New England Journal of Medicine·A Rosenfield
Jul 1, 1996·American Journal of Obstetrics and Gynecology·J K Jain, D R Mishell
Nov 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E G YaparO Gökmen
Apr 1, 1997·Obstetrics and Gynecology·L Sanchez-RamosF L Gaudier
Mar 24, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y Herabutya, P O-Prasertsawat
Aug 24, 1999·British Journal of Obstetrics and Gynaecology·G J HofmeyrZ Alfirevic
Sep 11, 1999·Obstetrical & Gynecological Survey·H C ScheepersA S van den Bergh
Aug 19, 2000·Clinical Obstetrics and Gynecology·P S Ramsey, J Owen
Jan 4, 2001·The New England Journal of Medicine·A B GoldbergP D Darney
May 12, 2001·American Journal of Obstetrics and Gynecology·B B Hogg, J Owen
Jan 5, 2002·Obstetrics and Gynecology·Y S ChongS Arulkumaran
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Jan E Dickinson, Sharon F Evans
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Michael W BebbingtonR Douglas Wilson
Feb 7, 2003·Gynecologic and Obstetric Investigation·Kirk D RaminPatrick S Ramsey

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Citations

Aug 4, 2006·Clinical Obstetrics and Gynecology·Jennifer G Smith, David C Merrill
Mar 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Z TabasiM Mahdian
Feb 12, 2009·Pakistan Journal of Biological Sciences : PJBS·M Behrashi, M Mahdian
Jun 15, 2011·Contraception·Lynn BorgattaUNKNOWN Society of Family Planning
Jan 21, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Maryam ZangenehMozhgan Rajatee
Jan 5, 2011·Taiwanese Journal of Obstetrics & Gynecology·Shi-Yann ChengShu-Chen Pei
Feb 19, 2008·Contraception·David K TurokRobert M Silver
Oct 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P C HoO S Tang
Aug 5, 2008·American Journal of Obstetrics and Gynecology·Jennifer HeinemannAndrew M Kaunitz
Sep 17, 2008·Reproductive Health Matters·Marc Bygdeman, Kristina Gemzell-Danielsson
Jan 2, 2007·Obstetrics and Gynecology·Robert M Silver
Jul 21, 2006·The Cochrane Database of Systematic Reviews·J P NeilsonJ Vazquez
Jun 18, 2019·The Cochrane Database of Systematic Reviews·Marike LemmersJames P Neilson
Feb 1, 2017·The Cochrane Database of Systematic Reviews·Caron KimLixia Dou
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Hajo WildschutNathalie Kapp
Jun 2, 2021·The Cochrane Database of Systematic Reviews·Jay GhoshIoannis D Gallos

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