Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study

American Journal of Obstetrics and Gynecology
Maria L BrizotMarcelo Zugaib

Abstract

The purpose of this study was to investigate the use of vaginal progesterone for the prevention of preterm delivery in twin pregnancies. We conducted a prospective, randomized, double-blind, placebo-controlled trial that involved 390 naturally conceived twin pregnancies among mothers with no history of preterm delivery who were receiving antenatal care at a single center. Women with twin pregnancies between 18 and 21 weeks and 6 days' gestation were assigned randomly to daily vaginal progesterone (200 mg) or placebo ovules until 34 weeks and 6 days' gestation. The primary outcome was the difference in mean gestational age at delivery; the secondary outcomes were the rate of spontaneous delivery at <34 weeks' gestation and the rate of neonatal composite morbidity and mortality in the treatment and nontreatment groups. The baseline characteristics were similar in both groups. The final analysis included 189 women in the progesterone group and 191 in the placebo group. No difference (P = .095) in the mean gestational age at delivery was observed between progesterone (35.08 ± 3.19 [SD]) and placebo groups (35.55 ± 2.85). The incidence of spontaneous delivery at <34 weeks' gestation was 18.5% in the progesterone group and 14.6% in t...Continue Reading

Associated Clinical Trials

Feb 23, 2017·Mario Henrique Burlacchini de Carvalho

References

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Citations

Dec 15, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·C A CombsUNKNOWN A Global Obstetrics Network (GONet) collaboration
Aug 24, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Isabela K R AgraMarcelo Zugaib
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