Vaginal versus Obstetric Infection Escherichia coli Isolates among Pregnant Women: Antimicrobial Resistance and Genetic Virulence Profile

PloS One
Emma Sáez-LópezSara M Soto

Abstract

Vaginal Escherichia coli colonization is related to obstetric infections and the consequent development of infections in newborns. Ampicillin resistance among E. coli strains is increasing, which is the main choice for treating empirically many obstetric and neonatal infections. Vaginal E. coli strains are very similar to extraintestinal pathogenic E. coli with regards to the virulence factors and the belonging to phylogroup B2. We studied the antimicrobial resistance and the genetic virulence profile of 82 E. coli isolates from 638 vaginal samples and 63 isolated from endometrial aspirate, placental and amniotic fluid samples from pregnant women with obstetric infections. The prevalence of E. coli in the vaginal samples was 13%, which was significant among women with associated risk factors during pregnancy, especially premature preterm rupture of membranes (p<0.0001). Sixty-five percent of the strains were ampicillin-resistant. The E. coli isolates causing obstetric infections showed higher resistance levels than vaginal isolates, particularly for gentamicin (p = 0.001). The most prevalent virulence factor genes were those related to the iron uptake systems revealing clear targets for interventions. More than 50% of the isola...Continue Reading

References

May 24, 2000·The Journal of Infectious Diseases·T A Russo, J R Johnson
Sep 30, 2000·Applied and Environmental Microbiology·O ClermontE Bingen
Mar 28, 2002·Infectious Diseases in Obstetrics and Gynecology·S W CookR A Hull
Jul 10, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Esko KankuriVilho Hiilesmaa
Jan 17, 2004·Clinical Microbiology Reviews·Herbert Schmidt, Michael Hensel
Mar 12, 2004·Molecular Biology and Evolution·Patricia Escobar-PáramoErick Denamur
Jun 12, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E BirosováL Valanský
May 19, 2005·Obstetrics and Gynecology Clinics of North America·Rodney K Edwards
May 31, 2006·PLoS Pathogens·Nat F BrownB Brett Finlay
Apr 10, 2009·Journal of Clinical Microbiology·Ziva PetkovsekMarjanca Starcic Erjavec
Jun 19, 2012·The Korean Journal of Internal Medicine·David M Livermore
Aug 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·Abdul Rahaman Shariff V ARadhakrishna M
Oct 5, 2013·Journal of Chemotherapy·Hugo Edgardo VillarMonica Beatriz Jugo
Jun 18, 2014·Postȩpy higieny i medycyny doświadczalnej·Ewelina KałużnaEugenia Gospodarek
Jul 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L SurgersUNKNOWN COLIBAFI Group
Sep 16, 2014·Analytical Chemistry·Kamonnaree ChotinantakulAlbert Schulte

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Citations

Jun 20, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·T HaahrT D Clausen
Jun 27, 2017·The Pediatric Infectious Disease Journal·Emma Sáez-LópezSara M Soto
Nov 15, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Nouf AbutheraaAlexander B Mullen
Jun 27, 2021·Trends in Microbiology·Dhrati V PatangiaR Paul Ross
Aug 27, 2021·Nature Reviews. Microbiology·Christina J Megli, Carolyn B Coyne

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Methods Mentioned

BETA
PCR
IEC

Software Mentioned

SPSS Statistics

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