Vaginocervical stimulation attenuates hindpaw shock-induced substance P release into spinal cord superfusates in rats

Brain Research
J L SteinmanB R Komisaruk

Abstract

The present study was designed to elucidate the mechanism in the spinal cord by which vaginocervical stimulation (VS) attenuates responses to noxious stimulation. This was accomplished by testing the hypothesis that VS reduces noxious stimulation-induced release of substance P at the level of the spinal cord. Noxious foot shock significantly increased the release of substance P (measured using radioimmunoassay) into superfusates of the lumbosacral spinal cord region in urethane-anesthetized rats. VS applied concurrently with foot shock significantly attenuated the release of substance P compared to the foot shock-only condition. In addition, substance P levels were significantly lower after the VS-only condition than after the no stimulation or foot shock-only conditions. These findings indicate that VS may produce analgesia, at least in part, by suppressing the release of substance P within the spinal cord.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A W MudgeG D Fischbach
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Apr 1, 1985·Pain·B Whipple, B R Komisaruk

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Citations

Sep 1, 1996·Physiology & Behavior·B M Johnson, B R Komisaruk
Jun 2, 2009·Brain Research Reviews·Kyle M BaumbauerRobin L Joynes
Aug 14, 2003·Scandinavian Journal of Psychology·Barry R Komisaruk, Giorgio Sansone

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