Vagotomy inhibits the effect of neurotensin on gastrointestinal transit in the rat

Acta Physiologica Scandinavica
P M Hellström

Abstract

Neurotensin has previously been shown to delay gastric emptying, gastrointestinal transit and ileo-caecal emptying in the rat. To investigate the vagal influence on these effects of neurotensin, separate groups of rats were operated with combined vagotomy and pyloroplasty or with pyloroplasty alone and compared to a group of normal rats. All animals were supplied with a permanent gastrointestinal catheter and a venous catheter. After operation the rats were allowed to recover for 7 days, and were fasted for 24 h prior to the experiments. A radioactive marker of 1.0-0.5 ml Na2(51)CrO4 in isotonic polyethylene glycol 400 was instilled intraluminally in the stomach, proximal or distal the small intestine. Saline (control animals) or neurotensin (test animals) was given i.v. in each group studied. The animals were killed at 15, 30, 60, and 120 min after administration of the marker. The distribution of the marker in the gastrointestinal tract was registered with a scintillation detector and quantitative analysis of the amount of radioactivity retained in separate gastrointestinal segments was carried out. Gastric emptying was delayed by combined vagotomy and pyloroplasty (P less than 0.01) compared to pyloroplasty alone and normals...Continue Reading

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Citations

Oct 1, 1989·Digestive Diseases and Sciences·M L Siegle, H J Ehrlein
Jan 1, 1989·Pharmacology & Therapeutics·G S Taylor, R A Bywater
Sep 16, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sara Gibbs, Teresa F DeGolier

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