Vagotomy prevents the effect of probiotics on caspase activity in a model of postmyocardial infarction depression

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Mandy MalickG Rousseau

Abstract

Myocardial infarction (MI) is associated with apoptosis in the amygdala and, ultimately, with clinical signs of depression. Different treatments have proven to be beneficial in preventing depression, including combination of the probiotics Lactobacillus helveticus and Bifidobacterium longum for prophylaxis. We have speculated previously that the benefit of these probiotics is due to their anti-inflammatory properties, and evidence suggests that an intact vagus nerve is important for this effect to occur. This study was designed to ascertain vagus nerve involvement in the beneficial influence of probiotics on caspase activities in our post-MI animal model of depression. Probiotics and/or vehicle were administered daily to male adult rats, 14 days before MI and until euthanasia. Vagotomy was performed in subgroups of rats 40 min before MI. They were sacrificed after 3 days of reperfusion, and MI size was assessed along with caspase-3 and -8 activities in the amygdala. Probiotics had no effect on infarct size but vagotomy increased it. Caspase-3 and caspase-8 activities in the amygdala were higher in MI than in sham-operated rats, and this outcome was reversed by probiotics. The beneficial influence of probiotics was abolished by ...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Jun 11, 2003·Archives of General Psychiatry·Nancy Frasure-Smith, François Lespérance
Oct 6, 2005·Biological Psychiatry·Boubacar Pasto WannGuy Rousseau
Jul 13, 2006·Apoptosis : an International Journal on Programmed Cell Death·M BoucherG Rousseau
Oct 2, 2007·Current Opinion in Gastroenterology·Monica Boirivant, Warren Strober
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hanneke van der KleijJohn Bienenstock
Jul 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Toshio WatanabeTetsuo Arakawa
Sep 4, 2009·Apoptosis : an International Journal on Programmed Cell Death·S KaloustianG Rousseau
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Oct 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P BercikE F Verdu
Apr 17, 2012·Autonomic Neuroscience : Basic & Clinical·E Marie SoutherlandJeffrey L Ardell
Jul 27, 2012·Journal of Neuroinflammation·Stanka MihaylovaBernhard Rosengarten
Jul 31, 2012·Brain, Behavior, and Immunity·M L HankeJ F Sheridan
Oct 11, 2012·Gastroenterology Research and Practice·Usha Vyas, Natarajan Ranganathan
Nov 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Azucena Perez-BurgosWolfgang Kunze
Nov 20, 2012·Psychoneuroendocrinology·K V ThrivikramanMichael J Owens
Nov 22, 2012·Nature Reviews. Endocrinology·Valentin A Pavlov, Kevin J Tracey
May 15, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A KhoshdelJ D Huizinga
Jan 1, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Ait-BelgnaouiT Tompkins
May 17, 2014·Current Behavioral Neuroscience Reports·Robert H Howland

❮ Previous
Next ❯

Citations

Feb 18, 2018·Molecular Nutrition & Food Research·Sandra TillmannRima Obeid
Oct 16, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dervla O'Malley
Jan 25, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R J MuldersR A H Adan
Feb 4, 2016·Current Opinion in Gastroenterology·Owen CroninFergus Shanahan
Feb 3, 2019·Medical Sciences : Open Access Journal·Alper EvrenselMehmet Emin Ceylan
Mar 15, 2018·Frontiers in Neuroscience·Maria M Buckley, Dervla O'Malley
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Ghazaleh MohammadiMarjan Nassiri-Asl
Feb 2, 2019·Gut Microbes·Alyssa DaltonMicah Zuhl
Dec 2, 2020·International Journal of Molecular Sciences·Sandor Haas-Neill, Paul Forsythe
Sep 12, 2017·Brain, Behavior, and Immunity·Alexandra Castillo-RuizNancy G Forger
Apr 23, 2021·Neuroscience Research·Yunpeng Liu, Paul Forsythe
May 1, 2021·International Journal of Molecular Sciences·Kévin NayJohn W Scott

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis