Vagus nerve stimulation in pediatric patients with failed epilepsy surgery.

Acta neurologica Belgica
Jeng-Dau TsaiVNS TCNS

Abstract

Adequate control of pharmacoresistant epilepsy continues to be a challenge. Multiple studies have reported the benefits of epilepsy surgery and vagus nerve stimulation for children with pharmacoresistant epilepsy. Little is known about the role of vagus nerve stimulation for children with failed epilepsy surgeries. The aim of this study was to examine the effects of vagus nerve stimulation on seizure frequency reduction for children with failed epilepsy surgeries. We retrospectively reviewed 85 children with pharmacoresistant epilepsy who underwent vagus nerve stimulation. Six of these patients underwent epilepsy surgery before vagus nerve stimulation (group I) and 79 patients received only vagus nerve stimulation (group II). We recorded seizure frequency at 3, 12, 24 and 36 months after vagus nerve stimulator implantation. Both groups had reduced seizure frequencies at the 3-, 12-, 24- and 36-month follow-up (p = 0.044 for group I trends and 0.008 for group II trends). Vagus nerve stimulator implantations significantly improve seizure frequency for children with or without previous epilepsy surgery at 3, 12, 24 and 36 months. These findings suggest that vagus nerve stimulation should be considered an alternative therapy for pe...Continue Reading

References

Jul 10, 2003·Lancet Neurology·Elinor Ben-Menachem
May 20, 2008·Lancet Neurology·Susan Spencer, Linda Huh
Jan 5, 2011·Seizure : the Journal of the British Epilepsy Association·Fernando L ValeSelim R Benbadis
May 3, 2011·Journal of Neurosurgery. Pediatrics·Robert E ElliottWerner K Doyle
Jul 10, 2012·Pediatrics and Neonatology·Chih-Yi ChenUNKNOWN Taiwan Child Neurology Society VNS Study Group
Jan 1, 2013·Seizure : the Journal of the British Epilepsy Association·Rebekka JungEkaterina Pataraia
May 29, 2013·Seizure : the Journal of the British Epilepsy Association·Rainer Surges, Christian E Elger
Jun 3, 2017·Journal of Neurosurgery. Pediatrics·Osama MuthaffarElysa Widjaja
Mar 14, 2018·Annals of Neurology·Vejay N VakhariaJerome Engel
Jun 24, 2018·Brain Sciences·Warren Boling

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Citations

Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Yue WangAilin Luo

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