Vagus nerve stimulation in refractory epilepsy: effects on pro- and anti-inflammatory cytokines in peripheral blood

Neuroimmunomodulation
H J M MajoieJ S H Vles

Abstract

The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an increase of neuroprotective tryptophan metabolites. Eleven patients with refractory epilepsy and 11 controls matched for age and gender were included in this study. The primary outcome measure was a 50% seizure reduction. Other variables were pro-inflammatory cytokines IL-6 and TNF-α, anti-inflammatory cytokine IL-10, cortisol, and the tryptophan metabolites 3-hydroxykynurenine (3-OH-KYN), kynurenic acid (KYNA), kynurenine, serotonin (5-HT) and 5-hydroxyindol acetic acid (5-HIAA). Blood samples were scheduled during baseline, and in week 28 of add-on treatment. IL-6 levels were higher in the responders than in the control group, and decreased after vagus nerve stimulation (VNS), whereas IL-10 was low and increased after VNS. In nonresponders, VNS resulted in an increase of IL-6 plasma levels and in a decrease of IL-10. Cortisol concentrations are higher in the epilepsy group than in the control group. After VNS, these concentrations decreased. The concentrations of the tryptophan metabolite...Continue Reading

Citations

Nov 4, 2011·Journal of Neuro-oncology·Bálint AlkonyiCsaba Juhász
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Sep 6, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Chengyuan Wu, Ashwini D Sharan
Oct 2, 2012·Gut·Gianluca Matteoli, Guy E Boeckxstaens
Dec 21, 2013·Trends in Neurosciences·Nicola MarchiDamir Janigro
May 17, 2014·Current Behavioral Neuroscience Reports·Robert H Howland
Sep 4, 2013·Journal of Neuroimmunology·Suvi LiimatainenPeltola Jukka
Mar 8, 2011·Epilepsy Research·Suvi LiimatainenMikko A Hurme
Sep 5, 2015·Journal of Neuroinflammation·Beatriz O AmorimClement Hamani
Mar 17, 2016·Anesthesiology·Benjamin E SteinbergPeder S Olofsson
Jan 11, 2011·Seizure : the Journal of the British Epilepsy Association·Gang LiHajo M Hamer
May 18, 2016·Brain, Behavior, and Immunity·Bradley J FergusonDavid Q Beversdorf
Dec 19, 2016·Gastroenterology·Kirsteen N BrowningGuy E Boeckxstaens
Jul 19, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chutima RoomruangwongMichael Maes
Aug 3, 2018·Nature Reviews. Gastroenterology & Hepatology·Keith A SharkeyDerek M McKay
Aug 3, 2017·Scandinavian Journal of Rheumatology·S E RasmussenC Brock
Jan 2, 2020·Practical Neurology·Laura Pérez-CarbonellGuy Leschziner
Aug 31, 2020·Epilepsia·Adriana M WorkewychGeorge M Ibrahim
Nov 1, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Laureen D HachemGeorge M Ibrahim
Sep 4, 2018·Neurosurgical Focus·Laureen D HachemGeorge M Ibrahim
Sep 13, 2020·Journal of Personalized Medicine·James Douglas BremnerOmer T Inan
Aug 25, 2019·Neurochemistry International·Jingxi MaZhiyou Cai
Apr 20, 2021·Epilepsy & Behavior : E&B·Tiziana GranataRima Nabbout
Sep 1, 2021·Expert Review of Medical Devices·Hilmar P SigurdssonAlison J Yarnall

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