Vagus nerve stimulation therapy in partial epilepsy: a review

Acta neurologica Belgica
Mariangela PanebiancoAntonino Pavone

Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked epileptic seizures. The majority of people given a diagnosis of epilepsy have a good prognosis, but 20-30 % will develop drug-resistant epilepsy. Vagus nerve stimulation (VNS) is a neuromodulatory treatment that is used as an adjunctive therapy for treating people with medically refractory epilepsy. It consists of chronic intermittent electrical stimulation of the vagus nerve, delivered by a programmable pulse generator (Neuro-Cybernetic Prosthesis). In 1997, the Food and Drug Administration approved VNS as adjunctive treatment for medically refractory partial-onset seizures in adults and adolescents. This article reviews the literature from 1988 to nowadays. We discuss thoroughly the anatomy and physiology of vagus nerve and the potential mechanisms of actions and clinical applications involved in VNS therapy, as well as the management, safety, tolerability and effectiveness of VNS therapy. VNS for partial seizures appears to be an effective and well tolerated treatment in adult and pediatric patients. People noted improvements in feelings of well-being, alertness, memory and thinking skills, as well as mood. The adverse effect profile is substa...Continue Reading

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Citations

Mar 29, 2018·Epilepsia Open·Yicong Lin, Yuping Wang
Jul 17, 2018·Epilepsia·Rod C ScottMarco de Curtis
Sep 10, 2019·Translational Neuroscience·Victor ConstantinescuDan Iulian Cuciureanu
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May 16, 2019·Journal of Korean Neurosurgical Society·Jeyul Yang, Ji Hoon Phi
Aug 28, 2020·International Journal of Environmental Research and Public Health·Carlo Efisio MarrasNelia Zamponi
Aug 21, 2019·CNS Neuroscience & Therapeutics·Jing-Jing FanQun Wang
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Oct 30, 2020·Seizure : the Journal of the British Epilepsy Association·Dènahin Hinnoutondji ToffaDang Khoa Nguyen

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