Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system

Clinical and Experimental Pharmacology & Physiology
Toshiro MatsuiTerukazu Kawasaki

Abstract

1. Intact absorption of the bioactive dipeptide Val-Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10-fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 +/- 145 vs 159 +/- 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t1/2) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 +/- 688 fmol small middle doth/mL plasma.

References

Nov 1, 1977·The Journal of Clinical Investigation·S A Adibi, E L Morse
Jun 1, 1984·The Journal of Nutrition·H HaraK Yamazaki
Nov 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·D B SilkD M Matthews
Oct 1, 1982·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·M L Gardner
Aug 1, 1995·Bioscience, Biotechnology, and Biochemistry·H MatsufujiY Osajima
Sep 25, 1999·Pharmaceutical Research·C Y YangC Pidgeon

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Citations

Sep 4, 2007·The British Journal of Nutrition·Caroline BauchartDidier Rémond
May 3, 2012·Journal of Agricultural and Food Chemistry·Yasutaka ShigemuraKenji Sato
May 24, 2011·Lipids in Health and Disease·Nao InoueTeruyoshi Yanagita
Oct 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Matsui ToshiroKiyoshi Matsumoto
Sep 17, 2009·Journal of Atherosclerosis and Thrombosis·Maria KimouliDemetrios A Spandidos
Nov 13, 2009·Journal of Atherosclerosis and Thrombosis·Kotaro AiharaMasayuki Yoshida
Oct 8, 2004·The British Journal of Nutrition·Vanessa VermeirssenWilly Verstraete
Jan 15, 2014·The Journal of Nutritional Biochemistry·Yasuaki Wada, Bo Lönnerdal
Jul 6, 2010·Peptides·Bahareh H Sarmadi, Amin Ismail
Aug 26, 2009·Regulatory Peptides·Flavia AxelbandAdalberto Vieyra
Apr 7, 2009·Regulatory Peptides·Flavia AxelbandAdalberto Vieyra
Sep 16, 2008·Peptides·Pieter C van der PijlNicolaas E P Deutz
Jan 29, 2008·Peptides·Lieselot VercruysseGuy Smagghe
Jan 28, 2015·Nutrition Research Reviews·Warren M Miner-WilliamsPaul J Moughan
Dec 16, 2017·Critical Reviews in Food Science and Nutrition·Melanie Martin, Andreas Deussen
Aug 27, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takao UenoKiyoshi Matsumoto
Dec 20, 2005·International Journal of Food Sciences and Nutrition·Vanessa VermeirssenWilly Verstraete
Jan 30, 2019·Applied Microbiology and Biotechnology·Jocksan I Morales-CamachoSilvia Luna-Suárez
Feb 3, 2021·Comprehensive Reviews in Food Science and Food Safety·Lu XuePangzhen Zhang
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Meisam BaratiAmin Mousavi Khaneghah
Aug 22, 2018·Journal of Agricultural and Food Chemistry·Beatriz MirallesIsidra Recio
Nov 12, 2014·Journal of Agricultural and Food Chemistry·Laura Sánchez-RiveraMaría Aránzazu Martínez
Nov 14, 2021·NPJ Science of Food·Yuna LeeToshiro Matsui

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