PMID: 11897923Mar 19, 2002Paper

Valdecoxib is more efficacious than rofecoxib in relieving pain associated with oral surgery

American Journal of Therapeutics
James R FrickeK M Verburg

Abstract

Inhibition of the cyclooxygenase (COX)-2 enzyme has been shown previously to reduce pain and inflammation. Valdecoxib is a new highly selective COX-2 inhibitor with a rapid onset of action and significant analgesic properties. This study compared the analgesic efficacy of valdecoxib and rofecoxib in treating postoperative pain in patients undergoing oral surgery. This randomized, double-blind, placebo-controlled study compared the efficacy of 40 mg valdecoxib with that of 50 mg rofecoxib and placebo. Efficacy was assessed by the onset of analgesia, pain intensity levels, and pain relief over 24 hours, time-weighted sum of total pain, sum of pain intensity difference, the percentage of patients requiring rescue medication and experiencing regimen failure, and patients' global evaluation. Patients receiving valdecoxib experienced a significantly quicker onset of analgesia, significantly improved pain relief, and lower pain intensity compared with patients receiving rofecoxib and greater satisfaction with their study medication after a single dose. Valdecoxib also demonstrated efficacy that was superior to that of rofecoxib with respect to the percentage of patients requiring rescue medication or experiencing regimen failure (p < ...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Jun 13, 1991·The New England Journal of Medicine·P M Brooks, R O Day
Feb 1, 1995·Acta Anaesthesiologica Scandinavica·D J FogartyK R Milligan
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SeibertP Isakson
Nov 1, 1993·Anesthesia and Analgesia·H Kehlet, J B Dahl
Sep 1, 1996·Journal of Clinical Anesthesia·H KehletT Callesen
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS

❮ Previous
Next ❯

Citations

Jul 11, 2003·Clinical Therapeutics·Mary L Chavez, Carrie J DeKorte
Feb 23, 2007·The Clinical Journal of Pain·Antonio XimenesRaul Vinueza
Dec 19, 2002·Drugs·Dirk O Stichtenoth, Jürgen C Frölich
May 18, 2007·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·K S KesavanarayananRaju Ilavarasan
Apr 15, 2009·Drug Development and Industrial Pharmacy·Sagar M Agnihotri, Pradeep R Vavia
Jan 9, 2007·Current Medical Research and Opinion·Jacques E ChellyAndrew M Tershakovec
Dec 4, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stephanie J LovellAdam J Singer
May 22, 2004·Journal of Clinical Pharmacy and Therapeutics·L-C ChenD M Ashcroft
May 4, 2004·Journal of Pain and Symptom Management·Kyle S Christensen, Gail D Cawkwell
Mar 15, 2005·Anesthesiology Clinics of North America·Noor M Gajraj, Girish P Joshi
Apr 15, 2005·Emergency Medicine Clinics of North America·Grant D Innes, Peter J Zed
Apr 22, 2015·The Journal of Pain : Official Journal of the American Pain Society·Neil SinglaRobert H Dworkin
Jun 21, 2006·Osteoarthritis and Cartilage·R W MoskowitzG D Cawkwell
Aug 1, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V BenetelloC F Santos
Dec 1, 2006·The Journal of International Medical Research·J A DiazJ Kohles
May 23, 2003·The Journal of International Medical Research·P BertinJ L Leroux
Feb 16, 2006·The American Journal of Sports Medicine·Evan F EkmanManuela F Berger
Sep 24, 2004·Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology·Yasemin Güneş, Geylan Işik
Oct 18, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sean Mackey
Apr 28, 2005·Expert Review of Neurotherapeutics·Girish P Joshi
Jan 7, 2005·Regional Anesthesia and Pain Medicine·Ian R CarrollJ David Clark
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Simon BulleyHenry J McQuay
Mar 19, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ji Y ZhangAlan P Breau
May 23, 2003·Anesthesia and Analgesia·Noor M Gajraj
Feb 19, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Andrea CicconettiAndrea Ripari
Jul 9, 2021·Organic & Biomolecular Chemistry·Dmitry A VasilenkoElena B Averina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.