Validated LC-MS-MS method for the determination of quetiapine in human plasma: application to a pharmacokinetic study

Journal of Chromatographic Science
Ryh-Nan PanLi-Heng Pao

Abstract

A sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for the determination of quetiapine was developed and validated over the linearity range 1-1500 ng/mL with 0.1 mL of plasma using clozapine as the internal standard. Detection was performed on a triple-quadrupole tandem mass spectrometer using positive electrospray ionization and quantification was performed by selected reaction monitoring mode. The MS-MS ion transitions monitored were m/z 384.1 → 253.1 and 327.0 → 270.0 for quetiapine and clozapine, respectively. The between- and within-run precision was less than 7.44% and accuracy was less than 10.2%. The lower limit of quantification was 1 ng/mL. The extraction recoveries of quetiapine were over 90%. The method is proved to be accurate and specific, and was applied to the pharmacokinetic study in healthy Chinese volunteers.

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Citations

Oct 16, 2013·Journal of Applied Toxicology : JAT·Olga López-GuarnidoAna M Bermejo
Dec 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisbeth PatteetHugo Neels
Jan 22, 2019·Bioanalysis·Maria Eugênia Costa QueirozJaime E Cecilio Hallak
Apr 2, 2015·Journal of Clinical Psychopharmacology·Michael PaulzenTanja Veselinovic
Dec 2, 2020·Journal of Pharmacological and Toxicological Methods·Benedicte JørgenrudThomas Berg

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