Validating a Monte Carlo approach to absolute dose quality assurance for proton pencil beam scanning

Physics in Medicine and Biology
Carla WinterhalterSairos Safai

Abstract

For radiotherapy, it is crucial to guarantee that the delivered dose matches the planned dose. Therefore, patient specific quality assurance (QA) of absolute dose distributions is necessary. Here, we investigate the potential of replacing patient specific QA for pencil beam scanned proton therapy with Monte Carlo simulations. First, the set-up of the automated Monte Carlo model is presented with an emphasis on the absolute dose validation. Second, the absolute dose results obtained from the Monte Carlo simulation for a comprehensive set of patient fields are compared to patient specific QA measurements. Absolute doses measured with the Farmer chamber are shown to be 1.4% higher than the doses measured with the Semiflex chamber. For single energy layers, Monte Carlo simulated doses are 2.1%  ±  0.4% lower than the ones measured with the ionization chamber and 1.1%  ±  1.0% lower than measurements compared to patient field verification measurements. After rescaling to account for this 1.1% discrepancy, 98 fields (94.2%) agree within 2% to measurements, the maximum difference being 2.3%. In conclusion, an automated, easy-to-use Monte Carlo calculation system has been set up. This system reproduced patient specific QA results over ...Continue Reading

References

Mar 11, 1999·Physics in Medicine and Biology·A Lomax
Apr 24, 2004·Zeitschrift für medizinische Physik·Eros PedroniGoran Kotle
Jul 28, 2011·Physics in Medicine and Biology·L GrevillotD Sarrut
Feb 15, 2012·Physics in Medicine and Biology·Benjamin ClasieHanne M Kooy
Aug 12, 2014·Physics in Medicine and Biology·C GomàS Safai
Dec 31, 2014·Physics in Medicine and Biology·C GrassbergerH Paganetti
Mar 31, 2015·Physics in Medicine and Biology·Carles GomàSándor Vörös
Jun 24, 2015·Journal of Applied Clinical Medical Physics·Liyong LinJames E McDonough
Sep 4, 2015·Physics in Medicine and Biology·K HenknerC P Karger
Nov 26, 2015·Technology in Cancer Research & Treatment·Joost Mathijs VerburgHarald Paganetti
Aug 19, 2016·Physics in Medicine and Biology·Carles GomàSairos Safai
Oct 22, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maria Francesca BelosiAntony J Lomax
Jan 18, 2018·Physics in Medicine and Biology·Pablo YepesRadhe Mohan

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Citations

Feb 1, 2020·The British Journal of Radiology·Carla WinterhalterSairos Safai
Jan 17, 2020·The British Journal of Radiology·Sara RosasJan Hrbacek
Aug 21, 2020·International Journal of Radiation Biology·Yinxiangzi ShengJingfang Zhao
Nov 24, 2020·Physics in Medicine and Biology·Harald PaganettiTony Lomax
Mar 28, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lena NenoffFrancesca Albertini
Feb 12, 2021·Physics in Medicine and Biology·Jeppe Brage ChristensenSairos Safai

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