Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence

Journal of Biomechanics
P Worth Longest, Samir Vinchurkar

Abstract

A number of computational fluid dynamics (CFD) studies have explored local deposition patterns of inhaled aerosols in the respiratory tract. These studies have highlighted the effects of multiple physiologic, geometric, and particle characteristics on deposition. However, very few studies have reported local or sub-branch quantitative comparisons to in vitro particle deposition data. The objective of this study is to numerically investigate the effects of transition and turbulence on highly localized particle deposition in a respiratory double bifurcation model in order to quantitatively validate CFD results. To perform the validations, local comparisons have been made to a specific in vitro case study of 10 microm particles depositing in a model of respiratory generations G3-G5. To achieve this objective, two geometric cases have been considered. The first case includes only the double bifurcation model. The second case includes a portion of the experimental particle delivery geometry, where transitional flow is expected. To evaluate the effectiveness of two-equation turbulence models in this system, the flow field solutions have been computed using laminar, standard k-omega, and low Reynolds number (LRN) k-omega approximation...Continue Reading

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Citations

Jan 24, 2007·Annals of Biomedical Engineering·Jinxiang Xi, P Worth Longest
Feb 21, 2013·Annals of Biomedical Engineering·P Worth LongestMichael Hindle
Mar 4, 2010·Pharmaceutical Research·Yuanyuan XieP Worth Longest
Feb 11, 2011·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Andrew R LambertChing-Long Lin
Apr 21, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Jian Hua ZhuDe Yun Wang
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Warren H Finlay, Andrew R Martin
Oct 30, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestSuparna Das Choudhuri
Oct 30, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth Longest, Michael Hindle
Mar 18, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
Jan 5, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Geng TianMichael Hindle
Jan 1, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
May 13, 2010·Journal of Biomechanical Engineering·Sudhaker Chhabra, Ajay K Prasad
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Dec 5, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
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May 7, 2015·Pharmaceutical Research·Geng TianP Worth Longest
Apr 16, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
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Jun 17, 2014·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Geng TianP Worth Longest
Jul 19, 2017·Pharmaceutical Research·James B FinkArmèle Dornelas de Andrade
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Sep 1, 2017·Journal of Biomechanical Engineering·Nikhil PaliwalHui Meng
Jun 1, 2013·Journal of Biomechanical Engineering·Ross L WalengaP Worth Longest

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