Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
S BiseniusMatthias L Schroeter

Abstract

Recently, diagnostic clinical and imaging criteria for primary progressive aphasia (PPA) have been revised by an international consortium (Gorno-Tempini et al. Neurology 2011;76:1006-14). The aim of this study was to validate the specificity of the new imaging criteria and investigate whether different imaging modalities [magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET)] require different diagnostic subtype-specific imaging criteria. Anatomical likelihood estimation meta-analyses were conducted for PPA subtypes across a large cohort of 396 patients: firstly, across MRI studies for each of the three PPA subtypes followed by conjunction and subtraction analyses to investigate the specificity, and, secondly, by comparing results across MRI vs. FDG-PET studies in semantic dementia and progressive nonfluent aphasia. Semantic dementia showed atrophy in temporal, fusiform, parahippocampal gyri, hippocampus, and amygdala, progressive nonfluent aphasia in left putamen, insula, middle/superior temporal, precentral, and frontal gyri, logopenic progressive aphasia in middle/superior temporal, supramarginal, and dorsal posterior cingulate gyri. Results of the disease-specific meta-analyses acros...Continue Reading

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Citations

Jun 9, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J ZhongL Sheng
Aug 11, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stefan TeipelUNKNOWN FTLDc study group
Jul 20, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S BiseniusM L Schroeter
Oct 17, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
May 28, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Lieke H H MeeterJohn C Van Swieten
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Jun 18, 2020·Frontiers in Aging Neuroscience·Matthias L SchroeterArno Villringer
Aug 4, 2019·Nature Communications·Michael A FergusonMichael D Fox
Nov 7, 2017·Frontiers in Neuroscience·Andreia V FariaSusumu Mori
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