Validating the management paradigm for pediatric spinal aneurysmal bone cysts to optimize long-term outcomes: an institutional experience.

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Victor M LuDavid J Daniels

Abstract

The optimal clinical management and outcomes of rare pediatric spinal aneurysmal bone cysts (spABC) is largely anecdotal. Current practice is based on bigger adult series, although given the disparities in spine growth of adults versus children, what impact this difference may have on long-term outcomes has yet to be substantiated. Correspondingly, the aim of this study was to describe the clinical course of all pediatric spABC cases managed at our institution to better understand this. A retrospective cohort study of all pediatric spABC cases presenting to our institution between 1993 and 2017 was performed using a predetermined set of selection criteria. Primary outcomes of interest were treatment modalities and their outcomes, recurrence status, and functional status. A total of 24 pediatric spABC cases satisfied all criteria. Median age of diagnosis was 13.5 years, with 15 females and 9 males. Radicular pain was the presenting symptom in 21 (88%) cases. Diagnostic biopsy was pursued in 9 (38%) cases, pre-operative embolization in 8 (33%) cases, surgical intervention in 23 (96%) cases, and sclerotherapy in 2 (8%) cases. In terms of surgery, there were no intraoperative complications, and gross total resection (GTR) was achie...Continue Reading

References

Aug 1, 1978·The Journal of Bone and Joint Surgery. British Volume·M C HayT K Taylor
Oct 1, 1987·Cancer·S B LanskyD R Miller
Nov 1, 1985·Journal of Neurosurgery·N O AmeliA Eslamdoost
Apr 8, 1998·Spine·P J PapagelopoulosK K Unni
Nov 12, 1998·Journal of Pediatric Orthopedics. Part B·M de KleuverB E Veraart
Jul 7, 1999·Archives of Orthopaedic and Trauma Surgery·T OzakiW Winkelmann
May 28, 2003·Pediatric Radiology·Josée DuboisLaurent Garel
Dec 16, 2004·Journal of Pediatric Orthopedics. Part B·Jérôme CottalordaAlain Dimeglio
Apr 16, 2005·Journal of Pediatric Orthopedics·Sumeet GargJohn P Dormans
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry J MankinMark C Gebhardt
Aug 29, 2006·Archives of Orthopaedic and Trauma Surgery·Jérôme Cottalorda, Sophie Bourelle
Dec 14, 2011·Journal of Pediatric Orthopedics. Part B·Loïc GeffroyAntoine Hamel
Dec 29, 2011·The Journal of Bone and Joint Surgery. American Volume·Eduardo N NovaisFranklin H Sim
Mar 3, 2012·Journal of Neurosurgery. Pediatrics·Georgios ZenonosMark R Proctor
Oct 12, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mehmet ZileliCem Calli
Apr 8, 2014·Case Reports in Oncological Medicine·Carlo BrembillaFrancesco Biroli
Jul 26, 2014·Journal of Neuro-oncology·Stefano BorianiUNKNOWN AOSpine Knowledge Forum Tumor
Feb 24, 2015·Journal of Pediatric Orthopedics·Amer SebaalyIsmat Ghanem
Feb 15, 2016·Orthopaedics & Traumatology, Surgery & Research : OTSR·F BatisseC Bonnard
Dec 10, 2016·International Orthopaedics·Giuseppe RossiCostantino Errani
May 30, 2017·Blood Cells, Molecules & Diseases·Michele HepponstallPaul Monagle
Nov 10, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Runqi WangqinZeguang Ren
May 16, 2019·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Sudhen B DesaiHoracio Padua

❮ Previous
Next ❯

Citations

Sep 27, 2020·Skeletal Radiology·Nehal SinglaAsif Saifuddin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Neurosurgery
R Kumar, K K Mukherjee
Acta orthopaedica Belgica
F Server PérezE Vidal Homs
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Leonel AmpieOrin Bloch
© 2021 Meta ULC. All rights reserved