Validating the pivotal role of the immune system in low-dose radiation-induced tumor inhibition in Lewis lung cancer-bearing mice

Cancer Medicine
Lei ZhouJiuwei Cui

Abstract

Although low-dose radiation (LDR) possesses the two distinct functions of inducing hormesis and adaptive responses, which result in immune enhancement and tumor inhibition, its clinical applications have not yet been elucidated. The major obstacle that hinders the application of LDR in the clinical setting is that the mechanisms underlying induction of tumor inhibition are unclear, and the risks associated with LDR are still unknown. Thus, to overcome this obstacle and elucidate the mechanisms mediating the antitumor effects of LDR, in this study, we established an in vivo lung cancer model to investigate the participation of the immune system in LDR-induced tumor inhibition and validated the pivotal role of the immune system by impairing immunity with high-dose radiation (HDR) of 1 Gy. Additionally, the LDR-induced adaptive response of the immune system was also observed by sequential HDR treatment in this mouse model. We found that LDR-activated T cells and natural killer cells and increased the cytotoxicity of splenocytes and the infiltration of T cells in the tumor tissues. In contrast, when immune function was impaired by HDR pretreatment, LDR could not induce tumor inhibition. However, when LDR was administered before HDR...Continue Reading

References

Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S WolffA Michaeli
Feb 1, 1995·International Journal of Radiation Biology·J F BarquineroJ Egozcue
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 11, 2004·Journal of Radiation Research·Shuji KojimaHirokazu Ishida
Jan 28, 2005·The British Journal of Radiology·L E Feinendegen
Jul 29, 2006·International Journal of Hygiene and Environmental Health·Wanwisa SudprasertMathuros Ruchirawat
Dec 29, 2006·Journal of Radiation Research·Akio ShigematsuSusumu Ikehara
Nov 26, 2008·Radiation Research·Hongyu JiangGuanjun Wang
Jan 21, 2010·Cancer Immunology, Immunotherapy : CII·Bohan DongLiying Wang
Aug 24, 2010·Radiation Research·Eniko Noémi BogdándiKatalin Lumniczky
May 11, 2011·Expert Review of Anticancer Therapy·Abdullah FarooqueBilikere S Dwarakanath
Oct 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Jonathan KaneGerard J Madlambayan
Jan 9, 2014·International Journal of Radiation Biology·Chi ZhangXuemian Lu
Mar 10, 2015·The Journal of Surgical Research·Rohit MittalMandy L Ford
Jun 9, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Martin LargeFranz Rödel
Jul 3, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David P CarboneLuis Paz-Ares
Jun 15, 2016·International Journal of Cancer. Journal International Du Cancer·Guozi YangJiuwei Cui

❮ Previous
Next ❯

Citations

May 30, 2019·International Journal of Radiation Biology·Stephanie PuukilaDani-Louise Dixon
Jul 3, 2020·Frontiers in Oncology·Jiarui ChenConghua Xie
Aug 12, 2018·Frontiers of Medicine·Minhong Shen, Yibin Kang
Jun 27, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiaodan LiuPingkun Zhou
Jul 2, 2019·Dose-response : a Publication of International Hormesis Society·Suhe DongJianming Cai
Aug 17, 2018·International Journal of Molecular Sciences·Eszter PersaKatalin Lumniczky
Nov 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edward J Calabrese, Walter J Kozumbo
Aug 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Roshal R PatelJames W Welsh
Oct 28, 2020·Journal for Immunotherapy of Cancer·Hampartsoum B BarsoumianJames Welsh
Jul 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Roshal R PatelJames W Welsh
Jul 16, 2021·International Journal of Radiation Biology·Calvin N LeungRoger W Howell

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
X‐ray

Software Mentioned

GraphPad Prism
SPSS
CBA
FlowJo

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.