Abstract
Much of the current literature on bipolar disorder is focused on bipolar I (BP-I), and to a much lesser extent on bipolar II (BP-II). The French multi-center national EPIDEP study has, among its objectives, the feasibility of validating a broader spectrum of bipolarity (the so-called "soft spectrum") by practicing clinicians. In this report we test aspects of a bipolar schema proposed earlier by Akiskal and Pinto [Akiskal, H.S., Pinto, O., 1999. The evolving bipolar spectrum: Prototypes I, II, III, IV. Psychiatr. Clin. North Am. 22: 517-534.]. EPIDEP was scheduled in three phases: Phase 1 to recruit DSM-IV major depressives; Phase 2 to assess hypomania and affective temperaments; and Phase 3 to obtain history on course of illness, family history, and comorbidity. Comparative analyses are presented between affective subgroups constructed on a hierarchical basis: spontaneous hypomania (BP-II), cyclothymic temperament (BP-II 1/2), antidepressant-associated hypomania (BP-III), hyperthymic temperament (BP-IV), versus "strict unipolar" (UP). We present data on 490 patients for whom we obtained full assessment during all three phases of the study, classified as BP-II 1/2 (N=164), II (N=61), III (N=28), IV (N=22), as well as UP (N=174)...Continue Reading
References
Oct 1, 1992·Journal of Affective Disorders·G B CassanoG Perugi
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Jan 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·D A BrentD Constantine
Apr 1, 1996·Journal of Clinical Psychopharmacology·H S Akiskal
Dec 19, 1998·Journal of Affective Disorders·E G HantoucheL Châtenet-Duchêne
Nov 7, 1999·The Psychiatric Clinics of North America·H S Akiskal, O Pinto
Feb 24, 2001·Journal of Personality Disorders·T M KellyJ J Mann
May 12, 2001·Comprehensive Psychiatry·E P AhearnB J Carroll
Apr 5, 2002·Suicide & Life-threatening Behavior·Jack D MaserPaula Clayton
Jan 1, 2003·Journal of Affective Disorders·Elie G HantoucheHagop S Akiskal
Jan 1, 2003·Journal of Affective Disorders·Hagop S AkiskalJean François Allilaire
Jan 1, 2003·Journal of Affective Disorders·Hagop S AkiskalSylvie Lancrenon
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Sep 17, 2004·Harvard Review of Psychiatry·Daniel J SmithDouglas H R Blackwood
Nov 4, 2004·Acta Psychiatrica Scandinavica·Hagop S Akiskal
Sep 24, 2005·Bipolar Disorders·Dean F MacKinnonUNKNOWN National Institutes of Mental Health Bipolar Disorder Genetics Initiative
Sep 24, 2005·Psychopathology·Hagop S Akiskal, Franco Benazzi
Jan 18, 2006·Bipolar Disorders·Dean F Mackinnon, Ronald Pies
Feb 7, 2006·Journal of Affective Disorders·Judit BalázsH S Akiskal
Citations
Sep 13, 2012·Journal of Abnormal Child Psychology·Anna Van MeterRobert L Findling
Mar 31, 2012·Clinical Psychology Review·Anna R Van MeterRobert L Findling
Oct 9, 2007·Current Opinion in Psychiatry·Jerome L Kroll
Apr 2, 2013·Neuropsychiatry·Anna R Van Meter, Eric A Youngstrom
Jun 12, 2013·Comprehensive Psychiatry·Alessandra Del CarloGiulio Perugi
Jun 27, 2009·Journal of Affective Disorders·Giuseppe MainaFilippo Bogetto
Feb 27, 2009·Journal of Affective Disorders·Benedikt AmannGregor Laakmann
Jan 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Franco Benazzi
Aug 19, 2007·Journal of Affective Disorders·Jack EdvardsenPer Anders Oien
May 23, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Franco Benazzi
Apr 21, 2010·Bipolar Disorders·Martin HoltmannSven Bölte
Jul 23, 2014·Bipolar Disorders·Kangguang LinTatia Mc Lee
Feb 5, 2010·Journal of Affective Disorders·G PerugiH S Akiskal
May 26, 2015·Journal of Affective Disorders·Giulio PerugiOlavo Pinto
Jun 10, 2008·Journal of Affective Disorders·H LövdahlU F Malt
Aug 9, 2012·Journal of Affective Disorders·Dominika DudekJanusz Rybakowski
Jul 17, 2013·Journal of Affective Disorders·Felice IasevoliAndrea de Bartolomeis
Aug 28, 2012·Journal of Affective Disorders·Carissa M CoulstonGin S Malhi
Mar 15, 2011·Journal of Affective Disorders·Anna Van MeterRobert L Findling
Sep 23, 2014·Journal of Affective Disorders·Marco InnamoratiMaurizio Pompili
Oct 19, 2010·Journal of Affective Disorders·Renee J ThompsonKeith Bredemeier
Feb 11, 2015·Journal of Affective Disorders·Atsushi KimuraMasaomi Iyo
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alessandro SerrettiDavid Rossini
Jun 2, 2010·L'Encéphale·J MasmoudiE G Hantouche
Oct 8, 2008·Journal of Psychopharmacology·Luísa W Bisol, Diogo R Lara
Jul 25, 2018·Neuropsychobiology·Stefano PorcelliUNKNOWN GECOBIP Group
Jan 7, 2016·Harvard Review of Psychiatry·Konstantinos N FountoulakisC Robert Cloninger
Aug 20, 2021·Culture, Medicine and Psychiatry·Fahimeh Mianji, Laurence J Kirmayer
Aug 17, 2021·Frontiers in Psychiatry·Zhe LuGuanglei Xun