Validating traditional Chinese syndrome features in varied stages of chronic gastritis malignant transformation: study protocol for a cross-sectional study

BMJ Open
Yin ZhangXia Ding

Abstract

The transition from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG) and gastric carcinoma (GC) is regarded as a representative disease model of gastric mucosa malignant transformation led by uncontrolled inflammation. Traditional Chinese medicine (TCM) syndrome-targeted therapies have been applied in treating chronic gastritis (CG) malignant transformation in China with satisfying efficacy. This study aims to validate TCM syndrome features in each stage of CG malignant transformation. The findings may shed light on the TCM hypothesis of CG malignant transformation, and thus optimise syndrome-targeted treatment strategies of CNAG, CAG and GC, respectively. The present study is a cross-sectional study conducted in China. A total of 2000 eligible patients, including 500 CNAG cases, 1000 CAG cases and 500 GC cases, will be recruited from four TCM hospitals. Primary outcome measures include the prevalence of TCM syndrome patterns in varied stages of CG malignant transformation. Secondary outcome measures include prevalence and severity of all the presenting signs and symptoms collected by using TCM four diagnostic methods. Descriptive analysis, comparative analysis and correlation analysis of all the measur...Continue Reading

Associated Clinical Trials

References

Mar 19, 2011·Journal of Clinical Gastroenterology·UNKNOWN World Gastroenterology Organisation
Dec 23, 2011·Journal of Digestive Diseases·Pelayo Correa, M Blanca Piazuelo
Apr 12, 2012·Gut·Peter MalfertheinerUNKNOWN European Helicobacter Study Group
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Sep 1, 2015·Journal of Digestive Diseases·Ping ChenXiao-Yu Chen

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Citations

Jul 11, 2019·Cell Communication and Signaling : CCS·Wang-Yu CaiQi-Cong Luo
Jul 22, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Baixue LiQuan-Sheng Feng

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Clinical Trials Mentioned

NCT03314038

Software Mentioned

SPSS
MATLAB
Office Excel
SPSS Clementine
SAS
Office Visio
R

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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