PMID: 20650166Dec 1, 1995Paper

Validation: A highly charged concept

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Herman B W M Koëter

Abstract

In order that a proposal for an alternative to an animal test be developed as an internationally accepted guideline, there needs to be consensus on the validity of the method proposed. Over the years, considerable attempts have been made to 'validate' promising alternatives. Probably without exception, these validation programmes demanded considerable budgets whereas the high expectations as to the output, which would justify the costs involved, were hardly ever met. What went wrong? Obviously, as for each new animal test, each new alternative to an animal test should be subjected to a critical appraisal procedure involving its scientific justification, its sensitivity and its reproducibility, before it could be internationally acceptable. Although there may be differences of opinion on the extent of this exercise, there is considerable agreement that validation in one way or another is essential. None the less, validation programmes so far have not resulted in the broad acceptance of any alternative test method. There may be two reasons for this failure. First, the results of the validation studies may have been unsatisfactory, which could mean that either the method subjected to validation failed to show the desired relevance...Continue Reading

References

Feb 1, 1991·Toxicology Letters·I KimberS J Waite
Jul 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J van den HeuvelA P Walker
Jan 1, 1994·Archives of Toxicology·W DienerE Schlede
Jan 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M K Prinsen, H B Koëter
Aug 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H B Koëter
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R H Clothier, M Balls
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·O BleinK G Dossou

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Citations

Jun 15, 1999·Medical & Biological Engineering & Computing·O DamourA F Black
Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Balls
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Lutz Edler, Carina Ittrich

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