Validation and Modification of the Japanese Classification System for Liver Metastases from Colorectal Cancer: A Multi-institutional Study

Annals of Surgical Oncology
Eiji ShintoStudy Group for Liver Metastasis projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR)

Abstract

A Japanese multicenter study disclosed four prognostic indicators of colorectal cancer liver metastases: ≥5 hepatic tumors (HT), HT size > 5 cm, nodal status (N2) of primary cancer, and the presence of extrahepatic metastases (EM). The Japanese classification was then defined as Stage A, HT1 (≤4 lesions and ≤5 cm) and N0/1; Stage B, HT2 (≥5 lesions or >5 cm) and N0/1, or HT1 and N2; and Stage C, HT2 and N2, HT3 (≥5 lesions and >5 cm) with any N, or EM1 (presence of EM) with any HT/N. This study aimed to validate the prognostic reliability in a recent population and to develop a modified staging system that divided Stage C patients. A total of 1185 patients diagnosed with liver metastases between 2007 and 2008 were enrolled in the study. According to the classification, 358, 257, and 570 patients were categorized as Stages A, B, and C, respectively. Stage C was further divided into two groups: Stage C-I, HT3 and N0/1, HT2 and N2, or HT1 and EM1; and Stage C-II, HT3 and N2, or HT2/3 and EM1. Cumulative overall survival curves for Stages A, B, and C were significantly different between each two stages (p < 0.0001, p < 0.0001). The modified system discriminated patients with a relatively better outcome (Stage C-I) from desperate pa...Continue Reading

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Citations

Feb 21, 2021·Journal of Hepato-biliary-pancreatic Sciences·Toru BeppuUNKNOWN Joint Committee for Nationwide Survey on Colorectal Liver Metastasis
Nov 21, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T YoshinoJ-Y Douillard
Sep 15, 2021·International Journal of Clinical Oncology·Mizuki NinomiyaHiroyuki Kuwano

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