Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats.

Psychopharmacology
Jonathan M HailwoodTimothy J Bussey

Abstract

Across species, effort-related motivation can be assessed by testing behaviour under a progressive ratio (PR) schedule of reinforcement. However, to date, PR tasks for rodents have been available using traditional operant response systems only. Touchscreen operant response systems allow the assessment of behaviour in laboratory rodents, using tasks that share high face validity with the computerised assessments used in humans. Here, we sought to optimise a rat touchscreen variant of PR and validate it by assessing the effects of a number of manipulations known to affect PR performance in non-touchscreen paradigms. Separate groups of male Sprague-Dawley rats were trained on PR schedules with either linear (PR4) or exponential (PREXP) schedules of reinforcement. PR performance was assessed in response to manipulations in reward outcome. Animals were tested under conditions of increased reward magnitude and following reward devaluation through a prefeeding procedure. Subsequently, the effects of systemic administration of the dopamine D2/D3 receptor antagonist raclopride and the psychostimulant d-amphetamine were examined as traditional pharmacological methods for manipulating motivation. Rats reinforced under PR4 and PREXP schedu...Continue Reading

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Citations

Nov 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan M HailwoodTimothy J Bussey
Nov 24, 2020·Physiology & Behavior·Tyler S GarmanCaitlin A Orsini
Mar 7, 2020·Genes, Brain, and Behavior·Julie R DumontFlavio Beraldo
Jul 9, 2021·Journal of the Experimental Analysis of Behavior·Forrest ToegelMichael Perone

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Software Mentioned

Prism
R
SPSS
ggplot2
GraphPad

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