Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology

Frontiers in Physiology
Pras Pathmanathan, Richard A Gray

Abstract

Computational models of cardiac electrophysiology have a long history in basic science applications and device design and evaluation, but have significant potential for clinical applications in all areas of cardiovascular medicine, including functional imaging and mapping, drug safety evaluation, disease diagnosis, patient selection, and therapy optimisation or personalisation. For all stakeholders to be confident in model-based clinical decisions, cardiac electrophysiological (CEP) models must be demonstrated to be trustworthy and reliable. Credibility, that is, the belief in the predictive capability, of a computational model is primarily established by performing validation, in which model predictions are compared to experimental or clinical data. However, there are numerous challenges to performing validation for highly complex multi-scale physiological models such as CEP models. As a result, credibility of CEP model predictions is usually founded upon a wide range of distinct factors, including various types of validation results, underlying theory, evidence supporting model assumptions, evidence from model calibration, all at a variety of scales from ion channel to cell to organ. Consequently, it is often unclear, or a ma...Continue Reading

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Citations

Mar 8, 2018·Journal of Cardiovascular Translational Research·Richard A Gray, Pras Pathmanathan
Feb 23, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Dominic G WhittakerGary R Mirams
Jan 18, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Richard A Gray, Michael R Franz
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May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Chon Lok LeiRichard D Wilkinson
Jul 13, 2019·Frontiers in Physiology·Pras PathmanathanRichard A Gray
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Aug 31, 2020·Communications in Nonlinear Science & Numerical Simulation·N CusimanoL Gerardo-Giorda
Aug 17, 2021·PLoS Computational Biology·Kathryn E MangoldJonathan R Silva

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Methods Mentioned

BETA
Assay

Software Mentioned

Web Lab
Web
Cardiac in vitro Proarrhythmia Assay ( CiPA )
CellML

Related Concepts

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Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.