Validation by serial standardized testing of a new rate-responsive pacemaker sensor based on variations in myocardial contractility

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
J ClémentyMichel Haissaguerre

Abstract

Preliminary studies have shown that peak endocardial acceleration (PEA), measured by a micro-accelerometer at the right ventricular apex, is highly correlated with left ventricular contractility (dp/dt max). Furthermore, changes in PEA are closely correlated with sinus node rate changes during exercise and during pharmacological interventions. Peak endocardial acceleration has, therefore, been used to drive a rate-responsive DDD pacemaker. This study compared the chronotropic performance of such devices implanted in 14 patients suffering from chronotropic incompetence with that observed in 18 control subjects in normal sinus rhythm. Five standardized daily life activities (hall walk, climbing up and down stairs, squatting and hyperventilation) and two types of exercise (Bruce treadmill protocol and bicycle ergometry) were performed in a random order after individual programming of each pacemaker. For each test, a correlation coefficient was calculated between changes in PEA and variations in paced rate, between instantaneous variations in heart rate monitored by telemetry and continuous measurement of heart rate by the pacemaker, and between sensor-driven rate in patients and normal sinus rhythm in controls. The variations in p...Continue Reading

Citations

Jan 16, 2002·Current Opinion in Cardiology·Satish R Raj, Robert S Sheldon
Nov 30, 2013·Journal of Healthcare Engineering·Stefania SacchiLuigi Padeletti
Dec 9, 2015·Pacing and Clinical Electrophysiology : PACE·Stefania SacchiLuigi Padeletti
Nov 18, 2004·Pacing and Clinical Electrophysiology : PACE·Ayten Erol-YilmazArthur Wilde
Nov 16, 2010·Journal of Cardiovascular Electrophysiology·Michael O Sweeney
Jun 26, 2015·IEEE Transactions on Bio-medical Engineering·Michael D EggenMatthew D Bonner

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