Validation of 3 T MRI including diffusion-weighted imaging for nodal staging of newly diagnosed intermediate- and high-risk prostate cancer

Clinical Radiology
Catrin von BelowMauritz Waldén

Abstract

To prospectively validate 3 T magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) for preoperative lymph node (LN) staging in a clinical setting, in intermediate- and high-risk prostate cancer (PCa) patients using laparoscopic extended LN dissection (ePLND) as the reference standard. Between August 2011 and May 2013, 40 newly diagnosed intermediate and high-risk PCa patients underwent preoperative LN staging with 3 T MRI DWI using histopathology of ePLND as the reference standard. The sensitivity, specificity, and accuracy of MRI DWI were calculated. A subgroup analysis of proven LN-positive patients was made to investigate differences in PSA, Gleason score, number, and size of LN metastases, estimated risk of LN involvement, and if curative treatment was indicated, between the true-positive and the false-negative groups. A total of 728 LN were harvested from six anatomical regions per patient (external, obturator, internal) with a mean number of 18 LNs per patient (range 11-40). Twenty patients had histologically proven LN-positive disease. MRI DWI was true positive in 11 patients, false negative in nine patients, false positive in two patients, and true negative in 18 patients, resulting in 90% specifi...Continue Reading

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Citations

Nov 7, 2017·World Journal of Radiology·Jessica G ZarzourSoroush Rais-Bahrami
Sep 16, 2018·Medical Oncology·Filippo PesapaneGeert Villeirs
Nov 27, 2018·Journal of Magnetic Resonance Imaging : JMRI·Young Il YoonHak Jong Lee
May 20, 2019·Radiology and Oncology·Iztok CaglicTristan Barrett
Mar 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Iztok CaglicTristan Barrett
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