Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Meira EppleinKai-Feng Pan

Abstract

Helicobacter pylori is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously, we developed and replicated serologic H. pylori biomarkers for gastric cancer risk among prospective cohorts in East Asia and now seek to validate the performance of these biomarkers in identifying individuals with premalignant lesions. This cross-sectional study included 1,402 individuals from Linqu County screened by upper endoscopy. H. pylori protein-specific antibody levels were assessed using multiplex serology. Multivariable-adjusted logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for prevalent intestinal metaplasia, indefinite dysplasia, or dysplasia, compared with superficial or mild atrophic gastritis. Compared with individuals seronegative to Omp and HP0305, individuals seropositive to both were seven times more likely to have precancerous lesions (OR, 7.43; 95% CI, 5.59-9.88). A classification model for precancerous lesions that includes age, smoking, and seropositivity to H. pylori, Omp, and HP0305 resulted in an area under the curve (AUC) of 0.751 (95% CI, 0.725-0.777), which is significantly better than the same model, in...Continue Reading

References

Feb 19, 2000·The American Journal of Surgical Pathology·M RuggeH Watanabe
Oct 26, 2002·Journal of Bacteriology·Nayoung KimGeorge Sachs
Aug 21, 2009·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kazumasa Miki, Mitsuhiro Fujishiro
Nov 6, 2009·Helicobacter·Angelika MichelMichael Pawlita
Jul 28, 2010·Molecular Microbiology·Annelie OlofssonAnna Arnqvist
Jul 12, 2011·Cancer Science·Hui-Lee WongWong-Ho Chow
Jul 23, 2011·Lancet·Luiz Edmundo MazzoleniGuilherme Becker Sander
Jan 25, 2012·Journal of the National Cancer Institute·Jun-Ling MaMitchell H Gail
Oct 5, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meira EppleinXiao-Ou Shu
Oct 25, 2013·International Journal of Cancer. Journal International Du Cancer·Kai-Feng PanMarkus Gerhard
Apr 29, 2014·Journal of Bacteriology·Bradley J VossTimothy L Cover
Jun 14, 2014·Journal of the National Cancer Institute·Wen-Qing LiMitchell H Gail
Feb 12, 2015·Helicobacter·Lorinda TurnerRichard L Ferrero
Apr 8, 2015·International Journal of Cancer. Journal International Du Cancer·Gwen MurphySanford M Dawsey
Jul 30, 2015·International Journal of Cancer. Journal International Du Cancer·Hadrien CharvatUNKNOWN JPHC Study Group
Sep 19, 2015·Cancer Research·Ramin ShakeriChristian C Abnet
Apr 23, 2016·Gastroenterology·Carlo A FalloneJohn K Marshall
May 14, 2016·International Journal of Epidemiology·Hui CaiMeira Epplein
Jul 16, 2016·Journal of the National Cancer Institute·Eva DoorakkersNele Brusselaers
Jul 30, 2016·The Lancet Global Health·Martyn PlummerSilvia Franceschi
Sep 10, 2017·Cancer Epidemiology·Nerea Fernández de Larrea-BazNuria Aragonés
Oct 19, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masahiro IidaToshiharu Ninomiya

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Citations

Sep 6, 2019·Helicobacter·Athanasios MakristathisEmilie Bessède
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Matthew G VargaMeira Epplein
Jun 3, 2021·Journal of Clinical Medicine·Maria Pina Dore, Giovanni Mario Pes

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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