Validation of a cholangiographic prognostic model in primary sclerosing cholangitis

Endoscopy
C Y PonsioenErik Schrumpf

Abstract

We previously developed a prognostic model for primary sclerosing cholangitis (PSC), which was primarily based on a cholangiographic classification of the intra- and extrahepatic biliary tree lesions. The aim of the present study was to validate the performance of this model in an external cohort. The validation dataset consisted of patients with PSC from a single referral center in Oslo, Norway. The patients' cholangiograms were scored according to the Amsterdam classification. We then examined whether adjusting the value of the original coefficients of the predictors or adding new predictors would improve the fit of the original model in the validation cohort. In addition, we evaluated calibration (closeness between observed and expected survival) and discrimination using the concordance index. A total of 111 patients (mean age 35 +/- 13 years; 76 % male) were included in the validation study. Baseline clinical characteristics were comparable between the two cohorts. None of the coefficients that were re-estimated in the validation cohort differed significantly from the values of the original model. Observed and expected survival curves were in close agreement across different risk groups. Discrimination of the original model...Continue Reading

Citations

Jul 19, 2013·Journal of Autoimmunity·Mohamad H ImamKeith D Lindor
Aug 21, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Palak J TrivediGideon M Hirschfield
Jan 1, 2014·Alimentary Pharmacology & Therapeutics·T H KarlsenK M Boberg
Sep 30, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyriel Y PonsioenGregory J Gores
Dec 30, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Johanna HaapamäkiMartti A Färkkilä
Feb 20, 2015·Current Opinion in Gastroenterology·Elisabeth M G de VriesCyriel Y Ponsioen
Aug 21, 2013·Scandinavian Journal of Gastroenterology·Henrike LenzenTim O Lankisch
Mar 10, 2017·Gastroenterology·Tobias J WeismüllerUNKNOWN International PSC Study Group
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Society of Gastrointestinal EndoscopyUNKNOWN European Association for the Study of the Liver
Aug 19, 2016·United European Gastroenterology Journal·Andrea TencaKaija-Leena Kolho
Nov 10, 2011·The American Journal of Gastroenterology·Khalid AlswatGideon M Hirschfield
Jun 9, 2018·Expert Review of Gastroenterology & Hepatology·James H Tabibian, Todd H Baron
Jun 15, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea TencaMartti Färkkilä
Mar 27, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyriel Y PonsioenLara Dimick-Santos
May 18, 2019·Journal of Digestive Diseases·James B Maurice, Douglas Thorburn
Oct 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Mark R DeneauStephen Guthery
Mar 1, 2016·World Journal of Hepatology·Jeremy S NayagamDeepak Joshi
May 29, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark R DeneauStephen L Guthery
Feb 18, 2014·Deutsches Ärzteblatt International·Holger LutzJens W Tischendorf
Mar 22, 2021·Health and Quality of Life Outcomes·Elena MarcusBella Vivat
May 10, 2020·Clinical Endoscopy·Purnima Bhat, Lars Aabakken
Jun 25, 2021·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Translational Research : the Journal of Laboratory and Clinical Medicine
Fred AskariGeorge J Brewer
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Roger Chapman
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Natalie A MolodeckyGilaad G Kaplan
© 2021 Meta ULC. All rights reserved