Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

Neurology
Caty CarreraSpanish Stroke Genetic Consortium

Abstract

To validate the Genot-PA score, a clinical-genetic logistic regression score that stratifies the thrombolytic therapy safety, in a new cohort of patients with stroke. We enrolled 1,482 recombinant tissue plasminogen activator (rtPA)-treated patients with stroke in Spain and Finland from 2003 to 2016. Cohorts were analyzed on the basis of ethnicity and therapy: Spanish patients treated with IV rtPA within 4.5 hours of onset (cohort A and B) or rtPA in combination with mechanical thrombectomy within 6 hours of onset (cohort C) and Finnish participants treated with IV rtPA within 4.5 hours of onset (cohort D). The Genot-PA score was calculated, and hemorrhagic transformation (HT) and parenchymal hematoma (PH) risks were determined for each score stratum. Genot-PA score was tested in 1,324 (cohort A, n = 726; B, n = 334; C, n = 54; and D, n = 210) patients who had enough information to complete the score. Of these, 213 (16.1%) participants developed HT and 85 (6.4%) developed PH. In cohorts A, B, and D, HT occurrence was predicted by the score (p = 2.02 × 10-6, p = 0.023, p = 0.033); PH prediction was associated in cohorts A through C (p = 0.012, p = 0.034, p = 5.32 × 10-4). Increased frequency of PH events from the lowest to the h...Continue Reading

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Mar 16, 2004·Lancet·Werner HackeUNKNOWN NINDS rt-PA Study Group Investigators
May 29, 2004·Stroke; a Journal of Cerebral Circulation·Mar CastellanosAntoni Dávalos
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Nov 6, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Brett CucchiaraScott Kasner
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Jukka PutaalaTurgut Tatlisumak
Nov 19, 2010·Nature Protocols·Carl A AndersonKrina T Zondervan
Jul 1, 2011·Neurology·D StrbianUNKNOWN Helsinki Stroke Thrombolysis Registry Group
Oct 12, 2011·Cerebrovascular Diseases·Bruce C V CampbellUNKNOWN EPITHET-DEFUSE Investigators
Apr 24, 2012·Annals of Neurology·Daniel StrbianTurgut Tatlisumak
Jan 3, 2013·Annals of Neurology·Alberto del Río-EspínolaJoan Montaner
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Hans T H TuUNKNOWN EPITHET-DEFUSE Investigators
Jun 4, 2013·Lancet Neurology·José Álvarez-SabínCarlos S Kase
Aug 1, 2014·PLoS Genetics·Elaine T LimUNKNOWN Sequencing Initiative Suomi (SISu) Project
Jan 8, 2015·Frontiers in Genetics·Shefali S VermaMarylyn D Ritchie
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
Aug 1, 2015·Nature Protocols·Elisabeth M van LeeuwenJouke Jan Hottenga
Oct 29, 2015·Stroke; a Journal of Cerebral Circulation·Xabier UrraUNKNOWN Catalan Stroke Code and Reperfusion Consortium
May 11, 2016·The New England Journal of Medicine·Craig S AndersonUNKNOWN ENCHANTED Investigators and Coordinators
Jun 4, 2016·Journal of the American College of Cardiology·Maxim MokinL Nelson Hopkins
Aug 19, 2016·Nature·Monkol LekUNKNOWN Exome Aggregation Consortium
Aug 23, 2018·Cerebrovascular Diseases·Elena López-CancioUNKNOWN Catalan Stroke Code and Reperfusion Consortium (Cat-SCR)

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Citations

Feb 23, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pavlos MyserlisChristopher D Anderson
Feb 27, 2021·Frontiers in Neurology·Guillaume CharbonnierThierry Moulin
Mar 20, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Arne LindgrenIsrael Cadenas
Jul 25, 2021·Journal of Clinical Medicine·Elena MuiñoThe Spanish Stroke Genetic Consortium
Mar 17, 2021·Brain : a Journal of Neurology·Caty CarreraIsrael Fernández-Cadenas
Oct 27, 2021·Pharmacogenomics·Laia Llucià-CarolIsrael Fernández-Cadenas

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